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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Step by Step about Germ Cells Development in Canine

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Author(s):
de Souza, Aline Fernanda [1] ; Pieri, Naira Caroline Godoy [1] ; Martins, Daniele dos Santos [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Fac Anim Sci & Food Engn, Dept Vet Med, BR-13635900 Pirassununga - Brazil
Total Affiliations: 1
Document type: Review article
Source: ANIMALS; v. 11, n. 3 MAR 2021.
Web of Science Citations: 0
Abstract

Simple Summary The progression of germ cells is a remarkable event that allows biological discovery in the differ-entiation process during in vivo and in vitro development. This is crucial for understanding one toward making oogenesis and spermatogenesis. Companion animals, such as canine, could offer new animal models for experimental and clinical testing for translation to human models. In this review, we describe the latest and more relevant findings on germ cell development. In addition, we showed the methods available for obtaining germ cells in vitro and the characterization of pri-mordial germ cells and spermatogonial stem cells. However, it is necessary to further conduct basic research in canine to clarify the beginning of germ cell development. Primordial germ cells (PGCs) have been described as precursors of gametes and provide a connection within generations, passing on the genome to the next generation. Failures in the formation of gametes/germ cells can compromise the maintenance and conservation of species. Most of the studies with PGCs have been carried out in mice, but this species is not always the best study model when transposing this knowledge to humans. Domestic animals, such as canines (canine), have become a valuable translational research model for stem cells and therapy. Furthermore, the study of canine germ cells opens new avenues for veterinary reproduction. In this review, the objective is to provide a comprehensive overview of the current knowledge on canine germ cells. The aspects of canine development and germ cells have been discussed since the origin, specifications, and development of spermatogonial canine were first discussed. Additionally, we discussed and explored some in vitro aspects of canine reproduction with germ cells, such as embryonic germ cells and spermatogonial stem cells. (AU)

FAPESP's process: 12/05609-0 - Xenogeneic-derived spermatogenesis after canine stem cell transplantation in murine testis
Grantee:Naira Caroline Godoy Pieri
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 16/15260-6 - Identification and migration route of canine primordial germ cells
Grantee:Eloise Cristina de Ramos
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 19/09148-7 - Multipotent stem cell characterization from feather follicle as a source to establish a genetic resource bank of wild birds
Grantee:Daniele dos Santos Martins
Support type: Regular Research Grants
FAPESP's process: 14/26761-0 - Reprogramming human embryonic germ cells
Grantee:Aline Fernanda de Souza
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 13/10542-5 - Epigenetic reprogramming of canine embryonic germ cells
Grantee:Aline Fernanda de Souza
Support type: Scholarships in Brazil - Doctorate