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Identification and migration route of canine primordial germ cells

Grant number: 16/15260-6
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): October 01, 2016
Effective date (End): September 30, 2017
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Reproduction
Principal researcher:Daniele dos Santos Martins
Grantee:Eloise Cristina de Ramos
Home Institution: Faculdade de Zootecnia e Engenharia de Alimentos (FZEA). Universidade de São Paulo (USP). Pirassununga , SP, Brazil


It is already known that the primordial germ cells (PGCs) in specific are capable to generate a new subject, they came from the gamets, which will transmit the genetic material to the future generations (CINALLI; RANGAN; LEHMANN, 2008). For each animal species, the primordial germ cells will have different time to migrate from their origin place to the gonadal ridge, where they will suffer differentiation to form feminine or masculine gonads. To differentiate to one or another sex, determinant genetic factors and specific cell markers will have essential functions. Understanding the full way and initial triggers to the migration and differentiation of these cells are relevant to identify and correct possible failures to these process, that will be important in the future to the reproductive development and performance of the individual studied. The domestic dog (Canis lupus familiaris) is na ideal model to study of the development in mammals because it has uncountable bichemical and physiological similarities to human. That is why, in this proposal it aims to identify the canine primordial germ cells at the embryo during the first, second and final gestational phases. To this procedure, we will make immunophenotipic descriptions with pluripotency and inicial germ cell markers OCT4 (POUF5) and germ cell marker VASA (DDX4). Our results aim to better understand the migration and differentiation process to the canine primordial germ cells, and it may be possible to apply somehow to humans.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE SOUZA, ALINE F.; DE RAMOS, ELOISE C.; CURY, FABIO S.; PIERI, NAIRA CAROLINE G.; MARTINS, DANIELE S. The timeline development of female canine germ cells. REPRODUCTION IN DOMESTIC ANIMALS, v. 54, n. 7, p. 964-971, JUL 2019. Web of Science Citations: 0.

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