Systemic dengue infection associated with a new dengue virus type 2 introduction in Brazil - a case report

Autor(es)

Cunha, Marielton dos Passos ^[1] ; Duarte-Neto, Amaro Nunes ^[2] ; Pour, Shahab Zaki ^[1] ; Hajjar, Ludhmila Abrahao ^[3] ; Frassetto, Fernando Pereira ^[2] ; Dolhnikoff, Marisa ^[2] ; do Nascimento Saldiva, Paulo Hilario ^[2] ; de Andrade Zanotto, Paolo Marinho ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Biomed Sci Inst, Dept Microbiol, Lab Mol Evolut & Bioinformat, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Med Sch, Pathol Dept, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Heart Inst InCor, Med Sch, Intens Care Unit, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BMC INFECTIOUS DISEASES; v. 21, n. 1 APR 1 2021.
• Citações Web of Science: 0

Resumo

BackgroundDengue infection is caused by an arbovirus with a wide range of presentations, varying from asymptomatic disease to unspecific febrile illness and haemorrhagic syndrome with shock, which can evolve to death. In Brazil, the virus circulates since the 1980s with many introductions of new serotypes, genotypes, and lineages since then. Here we report a fatal case of dengue associated with a Dengue virus (DENV) lineage not detected in the country until now.Case presentationThe patient, a 58-year-old man arrived at the hospital complaining of fever and severe abdominal pain due to intense gallbladder edema, mimicking acute abdomen. After 48h of hospital admission, he evolved to refractory shock and death. DENV RNA was detected in all tissues collected (heart, lung, brain, kidney, spleen, pancreas, liver, and testis). Viral sequencing has shown that the virus belongs to serotype 2, American/Asian genotype, in a new clade, which has never been identified in Brazil before. The virus was phylogenetically related to isolates from central America {[}Puerto Rico (2005-2007), Martinique (2005), and Guadeloupe (2006)], most likely arriving in Brazil from Puerto Rico.ConclusionIn summary, this was the first fatal documented case with systemic dengue infection associated with the new introduction of Dengue type 2 virus in Brazil during the 2019 outbreak. (AU)

• Processo FAPESP: 20/04602-9 - Desenvolvimento de antivirais para o tratamento da COVID-19
• Beneficiário: Glaucius Oliva
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/21728-2 - Uso de modernas técnicas de autópsia na investigação de doenças humanas (MODAU)
• Beneficiário: Paulo Hilário Nascimento Saldiva
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 17/23281-6 - Utilização de anticorpos que neutralizam a infecção após a adesão à célula para o desenvolvimento de estratégias imunoterápicas inovadoras exemplificadas pela destruição seletiva de células humanas infectadas pelo vírus Zika.
• Beneficiário: Paolo Marinho de Andrade Zanotto
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/08204-2 - Diversidade genética e filodinâmica dos arbovírus emergentes e reemergentes (DENV, ZIKV e CHIKV) nas regiões Nordeste e Sudeste do Brasil, 2014-2016
• Beneficiário: Marielton dos Passos Cunha
• Modalidade de apoio: Bolsas no Brasil - Doutorado