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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Systemic dengue infection associated with a new dengue virus type 2 introduction in Brazil - a case report

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Cunha, Marielton dos Passos [1] ; Duarte-Neto, Amaro Nunes [2] ; Pour, Shahab Zaki [1] ; Hajjar, Ludhmila Abrahao [3] ; Frassetto, Fernando Pereira [2] ; Dolhnikoff, Marisa [2] ; do Nascimento Saldiva, Paulo Hilario [2] ; de Andrade Zanotto, Paolo Marinho [1]
Total Authors: 8
[1] Univ Sao Paulo, Biomed Sci Inst, Dept Microbiol, Lab Mol Evolut & Bioinformat, Sao Paulo - Brazil
[2] Univ Sao Paulo, Med Sch, Pathol Dept, Sao Paulo - Brazil
[3] Univ Sao Paulo, Heart Inst InCor, Med Sch, Intens Care Unit, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: BMC INFECTIOUS DISEASES; v. 21, n. 1 APR 1 2021.
Web of Science Citations: 0

BackgroundDengue infection is caused by an arbovirus with a wide range of presentations, varying from asymptomatic disease to unspecific febrile illness and haemorrhagic syndrome with shock, which can evolve to death. In Brazil, the virus circulates since the 1980s with many introductions of new serotypes, genotypes, and lineages since then. Here we report a fatal case of dengue associated with a Dengue virus (DENV) lineage not detected in the country until now.Case presentationThe patient, a 58-year-old man arrived at the hospital complaining of fever and severe abdominal pain due to intense gallbladder edema, mimicking acute abdomen. After 48h of hospital admission, he evolved to refractory shock and death. DENV RNA was detected in all tissues collected (heart, lung, brain, kidney, spleen, pancreas, liver, and testis). Viral sequencing has shown that the virus belongs to serotype 2, American/Asian genotype, in a new clade, which has never been identified in Brazil before. The virus was phylogenetically related to isolates from central America {[}Puerto Rico (2005-2007), Martinique (2005), and Guadeloupe (2006)], most likely arriving in Brazil from Puerto Rico.ConclusionIn summary, this was the first fatal documented case with systemic dengue infection associated with the new introduction of Dengue type 2 virus in Brazil during the 2019 outbreak. (AU)

FAPESP's process: 20/04602-9 - Development of antivirals for the treatment of COVID-19
Grantee:Glaucius Oliva
Support type: Regular Research Grants
FAPESP's process: 13/21728-2 - The use of modern autopsy techniques to investigate human diseases (MODAU)
Grantee:Paulo Hilário Nascimento Saldiva
Support type: Research Projects - Thematic Grants
FAPESP's process: 17/23281-6 - The use of antibodies that neutralize infection at a post-attachment step for the development of innovative immunotherapeutic strategies exemplified for selective destruction of Zika-infected human cells.
Grantee:Paolo Marinho de Andrade Zanotto
Support type: Regular Research Grants
FAPESP's process: 16/08204-2 - Genetic and phylodynamics diversity of emerging and re-emerging arboviruses (DENV, ZIKV and CHIKV) in the Northeast and Southeast regions of Brazil, 2014-2016
Grantee:Marielton dos Passos Cunha
Support type: Scholarships in Brazil - Doctorate