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Yamaguchi, Guilherme Carvalho
[1]
;
Nemezio, Kleiner
[1]
;
Schulz, Mariane Leichsenring
[2]
;
Natali, Jose
[1]
;
Cesar, Jonatas Eduardo
[3]
;
Riani, Luiz Augusto
[1]
;
Goncalves, Livia De Souza
[1]
;
Moller, Gabriella Berwig
[1]
;
Sale, Craig
[4]
;
Gennari De Medeiros, Marisa Helena
[2]
;
Gualano, Bruno
[1]
;
Artioli, Guilherme Giannini
[1]
Número total de Autores: 12
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Appl Physiol & Nutr Res Grp, Sch Phys Educ & Sport, Rheumatol Div, Fac Med FMUSP, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Inst Quim, Dept Bioquim, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Dept Genet & Biol Evolut, Inst Biociencias, Sao Paulo, SP - Brazil
[4] Nottingham Trent Univ, Musculoskeletal Physiol Res Grp, Sport Hlth & Performance Enhancement Res Ctr, Nottingham - England
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | MEDICINE AND SCIENCE IN SPORTS AND EXERCISE; v. 53, n. 5, p. 1079-1088, MAY 2021. |
| Citações Web of Science: | 0 |
| Resumo | |
Purpose This study aimed to describe the kinetics of carnosine washout in human skeletal muscle over 16 wk. Methods Carnosine washout kinetics were studied in 15 young, physically active omnivorous men randomly assigned to take 6.4 g center dot d(-1) of beta-alanine (n = 11) or placebo (n = 4) for 8 wk. Muscle carnosine content (M-Carn) was determined before (PRE), immediately after (POST), and 4, 8, 12, and 16 wk after supplementation. High-intensity exercise tests were performed at these same time points. Linear and exponential models were fitted to the washout data, and the leave-one-out method was used to select the model with the best fit for M-Carn decay data. Repeated-measures correlation analysis was used to assess the association between changes in M-Carn and changes in performance. Results M-Carn increased from PRE to POST in the beta-alanine group only (+91.1% +/- 29.1%; placebo, +0.04% +/- 10.1%; P < 0.0001). M-Carn started to decrease after cessation of beta-alanine supplementation and continued to decrease until week 16 (POST4, +59% +/- 40%; POST8, +35% +/- 39%; POST12, +18% +/- 32%; POST16, -3% +/- 24% of PRE M-Carn). From week 12 onward, M-Carn was no longer statistically different from PRE. Both linear and exponential models displayed very similar fit and could be used to describe carnosine washout, although the linear model presented a slightly better fit. The decay in M-Carn was mirrored by a similar decay in high-intensity exercise tolerance; M-Carn was moderately and significantly correlated with total mechanical work done (r = 0.505; P = 0.032) and time to exhaustion (r = 0.72; P < 0.001). Conclusions Carnosine washout takes 12-16 wk to complete, and it can be described either by linear or exponential curves. Changes in M-Carn seem to be mirrored by changes in high-intensity exercise tolerance. This information can be used to optimize beta-alanine supplementation strategies. (AU) | |
| Processo FAPESP: | 13/07937-8 - Redoxoma |
| Beneficiário: | Ohara Augusto |
| Modalidade de apoio: | Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs |
| Processo FAPESP: | 17/13552-2 - Reduzindo tempo sedentário em populações clínicas: o estudo take a stand for health |
| Beneficiário: | Bruno Gualano |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 19/25032-9 - Papel da carnosina no manejo do Ca2+, controle do estresse oxidativo e na proteção à glicação proteica: avanços e aplicações do estudo vida sem carnosina |
| Beneficiário: | Hamilton Augusto Roschel da Silva |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 14/11948-8 - Vida sem carnosina: desenvolvimento e caracterização de um modelo de rato nocaute para estudo do papel fisiológico da carnosina e suas implicações para o exercício físico e metabolismo muscular |
| Beneficiário: | Guilherme Giannini Artioli |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 13/14746-4 - Metabolismo da carnosina no músculo esquelético: um estudo de múltiplas abordagens |
| Beneficiário: | Bruno Gualano |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |