The Role of Sialic Acids in the Establishment of Infections by Pathogens, With Special Focus on Leishmania

Autor(es)

Cavalcante, Taina ^[1] ; Medeiros, Mariana Medina ^[1] ; Mule, Simon Ngao ^[2] ; Palmisano, Giuseppe ^[2] ; Stolf, Beatriz Simonsen ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Lab Leishmaniasis, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, GlycoProte Lab, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY; v. 11, MAY 13 2021.
• Citações Web of Science: 1

Resumo

Carbohydrates or glycans are ubiquitous components of the cell surface which play crucial biological and structural roles. Sialic acids (Sias) are nine-carbon atoms sugars usually present as terminal residues of glycoproteins and glycolipids on the cell surface or secreted. They have important roles in cellular communication and also in infection and survival of pathogens. More than 20 pathogens can synthesize or capture Sias from their hosts and incorporate them into their own glycoconjugates and derivatives. Sialylation of pathogens' glycoconjugates may be crucial for survival inside the host for numerous reasons. The role of Sias in protozoa such as Trypanosoma and Leishmania was demonstrated in previous studies. This review highlights the importance of Sias in several pathogenic infections, focusing on Leishmania. We describe in detail the contributions of Sias, Siglecs (sialic acid binding Ig-like lectins) and Neuraminidase 1 (NEU 1) in the course of Leishmania infection. A detailed view on the structural and functional diversity of Leishmania-related Sias and host-cell receptors will be provided, as well as the results of functional studies performed with different Leishmania species. (AU)

• Processo FAPESP: 17/04032-5 - Dissecando a patogênese da Doença de Chagas através de abordagens glicômicas e glicoproteômicas
• Beneficiário: Simon Ngao Mule
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/18257-1 - EMU concedido no processo 14/06863-3: sistema de cromatografia líquida configurado para análise de carboidratos, aminoácidos, peptídeos e glicoproteínas
• Beneficiário: Giuseppe Palmisano
• Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários
• Processo FAPESP: 18/15549-1 - Modificações pós-traducionais nos processos biológicos e no diagnóstico da Doença de Chagas: novas abordagens metodológicas e implicações biológicas
• Beneficiário: Giuseppe Palmisano
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores - Fase 2
• Processo FAPESP: 18/14972-8 - Papel de sCD100 na infecção in vitro e in vivo por diferentes espécies de Leishmania
• Beneficiário: Beatriz Simonsen Stolf
• Modalidade de apoio: Auxílio à Pesquisa - Regular