| Full text | |
| Author(s): |
Cavalcante, Taina
[1]
;
Medeiros, Mariana Medina
[1]
;
Mule, Simon Ngao
[2]
;
Palmisano, Giuseppe
[2]
;
Stolf, Beatriz Simonsen
[1]
Total Authors: 5
|
| Affiliation: | [1] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Lab Leishmaniasis, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, GlycoProte Lab, Sao Paulo - Brazil
Total Affiliations: 2
|
| Document type: | Review article |
| Source: | FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY; v. 11, MAY 13 2021. |
| Web of Science Citations: | 1 |
| Abstract | |
Carbohydrates or glycans are ubiquitous components of the cell surface which play crucial biological and structural roles. Sialic acids (Sias) are nine-carbon atoms sugars usually present as terminal residues of glycoproteins and glycolipids on the cell surface or secreted. They have important roles in cellular communication and also in infection and survival of pathogens. More than 20 pathogens can synthesize or capture Sias from their hosts and incorporate them into their own glycoconjugates and derivatives. Sialylation of pathogens' glycoconjugates may be crucial for survival inside the host for numerous reasons. The role of Sias in protozoa such as Trypanosoma and Leishmania was demonstrated in previous studies. This review highlights the importance of Sias in several pathogenic infections, focusing on Leishmania. We describe in detail the contributions of Sias, Siglecs (sialic acid binding Ig-like lectins) and Neuraminidase 1 (NEU 1) in the course of Leishmania infection. A detailed view on the structural and functional diversity of Leishmania-related Sias and host-cell receptors will be provided, as well as the results of functional studies performed with different Leishmania species. (AU) | |
| FAPESP's process: | 17/04032-5 - Dissecting the pathogenesis of Chagas Disease by deep glycomics and glycoproteomics approaches |
| Grantee: | Simon Ngao Mule |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 18/18257-1 - Multi-user equipment approved in grant 14/06863-3: HPLC system configured for analysis of carbohydrates, amino acidis, peptides and glycoproteins |
| Grantee: | Giuseppe Palmisano |
| Support Opportunities: | Multi-user Equipment Program |
| FAPESP's process: | 18/15549-1 - Post-translational modifications in Chagas Disease biological processes and diagnostics: novel methodological approaches and biological applications |
| Grantee: | Giuseppe Palmisano |
| Support Opportunities: | Research Grants - Young Investigators Grants - Phase 2 |
| FAPESP's process: | 18/14972-8 - Role of sCD100 in in vitro and in vivo infection by different species of Leishmania |
| Grantee: | Beatriz Simonsen Stolf |
| Support Opportunities: | Regular Research Grants |