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Multi-user equipment approved in grant 14/06863-3: HPLC system configured for analysis of carbohydrates, amino acidis, peptides and glycoproteins

Grant number: 18/18257-1
Support type:Multi-user Equipment Program
Duration: November 01, 2018 - October 31, 2025
Field of knowledge:Biological Sciences - Biochemistry - Chemistry of Macromolecules
Principal researcher:Giuseppe Palmisano
Grantee:Giuseppe Palmisano
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:14/06863-3 - Post-translational modifications in cancer and parasite infection diagnosis: methodological approaches and biological implications, AP.JP
As informações de acesso ao Equipamento Multiusuário são de responsabilidade do Pesquisador responsável
EMU web page:https://sites.usp.br/proteomics/equipamentos-multiusuario/
Type of equipment:Caracterização de Materiais - Análises Químicas - Cromatrografia líquida
Manufacturer: Thermo Scientific
Model: ICS + detectores UV + fluorescência + eletroquímico

Abstract

We aim at building an analytical platform for glycan identification and quantification. The analysis of mono, oligo and polysaccharides will offer the possibility of studying the modulation of the cellular, tissue and biofluid glycome in different biological systems. Differential glycan expression has been associated to several diseases from cancer, infectious diseases and others. In particular, glycoproteins, glycolipids, proteoglycans, and other glycoconjugates have been suggested as possible candidate biomarkers and therapeutic targets. Due to that, their analysis and structural characterization is important to fully elucidate the glycome in pathophysiological conditions. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MULE, S. N.; MANCHOLA, N. C.; DE OLIVEIRA, G. S.; PEREIRA, M.; MAGALHAES, R. D. M.; TEIXEIRA, A. A.; COLLI, W.; ALVES, M. J. M.; PALMISANO, G. Proteome-wide modulation of S-nitrosylation in Trypanosoma cruzi trypomastigotes upon interaction with the host extracellular matrix. JOURNAL OF PROTEOMICS, v. 231, JAN 16 2021. Web of Science Citations: 0.
MARTINS, LARISSA ALMEIDA; PALMISANO, GIUSEPPE; CORTEZ, MAURO; KAWAHARA, REBECA; DE FREITAS BALANCO, JOSE MARIO; FUJITA, ANDRE; ALONSO, BEATRIZ IGLESIAS; BARROS-BATTESTI, DARCI MORAES; BRAZ, GLORIA REGINA CARDOSO; TIRLONI, LUCAS; ESTEVES, ELIANE; DAFFRE, SIRLEI; FOGACA, ANDREA CRISTINA. The intracellular bacterium Rickettsia rickettsii exerts an inhibitory effect on the apoptosis of tick cells. PARASITES & VECTORS, v. 13, n. 1 DEC 1 2020. Web of Science Citations: 0.
RODRIGUES, MARIANE A. D.; PIMENTA, MARCELA V.; COSTA, IRIS M.; ZENATTI, PRISCILA P.; MIGITA, NATACHA A.; YUNES, JOSE A.; RANGEL-YAGUI, CARLOTA O.; DE SA, MATHEUS M.; PESSOA, ADALBERTO; COSTA-SILVA, TALES A.; TOYAMA, MARCOS H.; BREYER, CARLOS A.; DE OLIVEIRA, MARCOS A.; SANTIAGO, VERONICA F.; PALMISANO, GIUSEPPE; BARBOSA, CHRISTIANO M. V.; HEBEDA, CRISTINA B.; FARSKY, SANDRA H. P.; MONTEIRO, GISELE. Influence of lysosomal protease sensitivity in the immunogenicity of the antitumor biopharmaceutical asparaginase. Biochemical Pharmacology, v. 182, DEC 2020. Web of Science Citations: 0.
ROSA-FERNANDES, LIVIA; BARBOSA, RAQUEL HORA; DOS SANTOS, MARIA LUIZA B.; ANGELI, CLAUDIA B.; SILVA, THIAGO P.; MELO, ROSSANA C. N.; DE OLIVEIRA, GILBERTO SANTOS; LEMOS, BERNARDO; VAN EYK, JENNIFER E.; LARSEN, MARTIN R.; CARDOSO, CLAUDETE ARAUJO; PALMISANO, GIUSEPPE. Cellular Imprinting Proteomics Assay: A Novel Method for Detection of Neural and Ocular Disorders Applied to Congenital Zika Virus Syndrome. JOURNAL OF PROTEOME RESEARCH, v. 19, n. 11, p. 4496-4515, NOV 6 2020. Web of Science Citations: 1.
GAVINHO, BRUNO; SABATKE, BRUNA; FEIJOLI, VERONICA; ROSSI, IZADORA VOLPATO; DA SILVA, JANAINA MACEDO; EVANS-OSSES, INGRID; PALMISANO, GIUSEPPE; LANGE, SIGRUN; RAMIREZ, MARCEL IVAN. Peptidylarginine Deiminase Inhibition Abolishes the Production of Large Extracellular Vesicles FromGiardia intestinalis, Affecting Host-Pathogen Interactions by Hindering Adhesion to Host Cells. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 10, SEP 23 2020. Web of Science Citations: 1.
MISERANI MAGALHAES, RUBENS DANIEL; MATTOS, ELICIANE CEVOLANI; ROZANSKI, ANDREI; FAVORETTO GALANTE, PEDRO ALEXANDRE; PALMISANO, GIUSEPPE; CRUZ, ANGELA KAYSEL; COLLI, WALTER; CAMARGO, ANAMARIA ARANHA; MANSO ALVES, MARIA JULIA. Global changes in nitration levels and DNA binding profile of Trypanosoma cruzi histones induced by incubation with host extracellular matrix. PLoS Neglected Tropical Diseases, v. 14, n. 5 MAY 2020. Web of Science Citations: 1.
LIMA, GUILHERME MEIRA; EFFER, BRIAN; BIASOTO, HENRIQUE PELLIN; FEIJOLI, VERONICA; PESSOA, ADALBERTO; PALMISANO, GIUSEPPE; MONTEIRO, GISELE. Glycosylation of L-asparaginase from E. coli through yeast expression and site-directed mutagenesis. Biochemical Engineering Journal, v. 156, APR 15 2020. Web of Science Citations: 0.
KAWAHARA, REBECA; RECUERO, SAULO; NOGUEIRA, FABIO C. S.; DOMONT, GILBERTO B.; LEITE, KATIA R. M.; SROUGI, MIGUEL; THAYSEN-ANDERSEN, MORTEN; PALMISANO, GIUSEPPE. Tissue Proteome Signatures Associated with Five Grades of Prostate Cancer and Benign Prostatic Hyperplasia. PROTEOMICS, v. 19, n. 21-22, SI NOV 2019. Web of Science Citations: 0.
CAPELLI-PEIXOTO, JANAINA; MULE, SIMON NGAO; TANO, FABIA TOMIE; PALMISANO, GIUSEPPE; STOLF, BEATRIZ SIMONSEN. Proteomics and Leishmaniasis: Potential Clinical Applications. PROTEOMICS CLINICAL APPLICATIONS, v. 13, n. 6 AUG 2019. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.