The Role of GPNMB in Inflammation

Autor(es)

Saade, Marina ^[1] ; de Souza, Giovanna Araujo ^[1] ; Scavone, Cristoforo ^[1] ; Kinoshita, Paula Fernanda ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: FRONTIERS IN IMMUNOLOGY; v. 12, MAY 12 2021.
• Citações Web of Science: 0

Resumo

Inflammation is a response to a lesion in the tissue or infection. This process occurs in a specific manner in the central nervous system and is called neuroinflammation, which is involved in neurodegenerative diseases. GPNMB, an endogenous glycoprotein, has been recently related to inflammation and neuroinflammation. GPNMB is highly expressed in macrophages and microglia, which are cells involved with innate immune response in the periphery and the brain, respectively. Some studies have shown increased levels of GPNMB in pro-inflammatory conditions, such as LPS treatment, and in pathological conditions, such as neurodegenerative diseases and cancer. However, the role of GPNMB in inflammation is still not clear. Even though most studies suggest that GPNMB might have an anti-inflammatory role by promoting inflammation resolution, there is evidence that GPNMB could be pro-inflammatory. In this review, we gather and discuss the published evidence regarding this interaction. (AU)

• Processo FAPESP: 18/14289-6 - O papel da proteína Klotho na doença de Alzheimer
• Beneficiário: Paula Fernanda Kinoshita
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 16/07427-8 - Envelhecimento e neuroproteção: ações da proteína Klotho no metabolismo energético, sinalização da Na,K-ATPase e respostas adaptativas no sistema nervoso central
• Beneficiário: Cristoforo Scavone
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 19/05970-4 - Efeitos da proteína ±-Klotho na sinalização do TNF-± via TNFR1 em cultura primária de células da glia
• Beneficiário: Giovanna Araujo de Souza
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 18/07896-3 - Efeitos da proteína GPNMB na modulação de processos inflamatórios causados pelo LPS em células da microglia e astrócitos de ratos
• Beneficiário: Marina Saade
• Modalidade de apoio: Bolsas no Brasil - Mestrado