Ventricular Fibrosis and Coronary Remodeling Following Short-Term Exposure of Healthy and Malnourished Mice to Bisphenol A

Autor(es)

Garcia-Arevalo, Marta ^{[1, 2]} ; Lorza-Gil, Estela ^{[1, 2]} ; Cardoso, Leandro ^[2] ; Batista, Thiago Martins ^{[1, 2]} ; Araujo, Thiago Reis ^{[1, 2]} ; Ferreira Ramos, Luiz Alberto ^[2] ; Areas, Miguel Arcanjo ^[2] ; Nadal, Angel ^[3] ; Carneiro, Everardo Magalhaes ^{[1, 2]} ; Davel, Ana Paula ^[2]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Obes & Comorbid Res Ctr OCRC, Campinas - Brazil

^[2] Inst Biol, Dept Struct & Funct Biol, Campinas - Brazil

^[3] Univ Miguel Hernandez, Spanish Biomed Res Ctr Diabet & Associated Metab, Inst Biol Mol & Celular, Inst Invest Desarrollo Innovac Biotecnol Sanitari, Elche - Spain

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN PHYSIOLOGY; v. 12, APR 12 2021.
• Citações Web of Science: 0

Resumo

Bisphenol-A (BPA) is an endocrine disruptor associated with higher risk of insulin resistance, type 2 diabetes, and cardiovascular diseases especially in susceptible populations. Because malnutrition is a nutritional disorder associated with high cardiovascular risk, we sought to compare the effects of short-term BPA exposure on cardiovascular parameters of healthy and protein-malnourished mice. Postweaned male mice were fed a normo- (control) or low-protein (LP) diet for 8 weeks and then exposed or not to BPA (50 mu g kg(-1) day(-1)) for the last 9 days. Systolic blood pressure was higher in BPA or LP groups compared with the control group. However, diastolic blood pressure was enhanced by BPA only in malnourished mice. Left ventricle (LV) end diastolic pressure (EDP), collagen deposition, and CTGF mRNA expression were higher in the control or malnourished mice exposed to BPA than in the respective nonexposed groups. Nevertheless, mice fed LP diet exposed to BPA exhibited higher angiotensinogen and cardiac TGF-beta 1 mRNA expression than mice treated with LP or BPA alone. Wall:lumen ratio and cross-sectional area of intramyocardial arteries were higher either in the LP or BPA group compared with the control mice. Taken together, our data suggest that short-term BPA exposure results in LV diastolic dysfunction and fibrosis, and intramyocardial arteries inward remodeling, besides potentiate protein malnutrition-induced hypertension and cardiovascular risk. (AU)

• Processo FAPESP: 18/26080-4 - Caracterização dos mecanismos moleculares e funcionais envolvidos nas disfunções endócrino-metabólicas, cardiovasculares e neurais induzidas pela restrição de aminoácidos in vitro e in vivo: possível papel terapêutico do ácido biliar TUDCA
• Beneficiário: Everardo Magalhães Carneiro
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 14/09532-8 - Análise funcional e molecular dos receptores de estrógenos em ilhotas de Langerhans e tecidos periféricos de camundongos desnutridos e seu envolvimento com o controle glicêmico
• Beneficiário: Marta García-Arévalo Provencio
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 14/01717-9 - Investigação dos efeitos insulinotrópicos, insulinomiméticos e endoteliais da taurina em células/tecidos submetidos à restrição in vitro de aminoácidos: uma abordagem integrada e multifocal
• Beneficiário: Everardo Magalhães Carneiro
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/07607-8 - CMPO - Centro Multidisciplinar de Pesquisa em Obesidade e Doenças Associadas
• Beneficiário: Licio Augusto Velloso
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs