Stromal cell interplay in prostate development, physiology, and pathological conditions

Autor(es)

Sanches, Bruno D. A. ^[1] ; Maldarine, Juliana S. ^[1] ; Vilamaior, Patricia S. L. ^[2] ; Felisbino, Sergio L. ^{[3, 1]} ; Carvalho, Hernandes F. ^[1] ; Taboga, Sebastiao R. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] State Univ Campinas UNICAMP, Inst Biol, Dept Struct & Funct Biol, Campinas - Brazil

^[2] Sao Paulo State Univ UNESP, Dept Biol Sci, Lab Microscopy & Microanal, Cristovao Colombo St 2265, Sao Jose Do Rio Preto, SP - Brazil

^[3] Sao Paulo State Univ UNESP, Inst Biosci, Botucatu, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: PROSTATE; v. 81, n. 13 JUL 2021.
• Citações Web of Science: 0

Resumo

Advances in prostatic stroma studies over the past few decades have demonstrated that the stroma not only supports and nourishes the gland's secretory epithelium but also participates in key aspects of morphogenesis, in the prostate's hormonal metabolism, and in the functionality of the secretory epithelium. Furthermore, the stroma is implicated in the onset and progression of prostate cancer through the formation of the so-called reactive stroma, which corresponds to a tumorigenesis-permissive microenvironment. Prostatic stromal cells are interconnected and exchange paracrine signals among themselves in a gland that is highly sensitive to endocrine hormones. There is a growing body of evidence that telocytes, recently detected interstitial cells that are also present in the prostate, are involved in stromal organization, so that their processes form a network of interconnections with both the epithelium and the other stromal cells. The present review provides an update on the different types of prostate stromal cells, their interrelationships and implications for prostate development, physiology and pathological conditions. (AU)

• Processo FAPESP: 18/08945-8 - Telócitos, células musculares lisas, miofibroblastos e fibroblastos prostáticos: origem, interrelações e transdiferenciação.
• Beneficiário: Bruno Domingos Azevedo Sanches
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 18/23383-6 - Repercussões histopatológicas da ação dos desreguladores endócrinos bisfienol-A e 17-beta-estradiol sobre glândulas mamárias e próstata feminina do Gerbilo da Mongólia e suas relações com a carcinogênese quimicamente induzida pelo MNU
• Beneficiário: Sebastião Roberto Taboga
• Modalidade de apoio: Auxílio à Pesquisa - Regular