Stromal cell interplay in prostate development, physiology, and pathological conditions

Author(s)

Sanches, Bruno D. A. ^[1] ; Maldarine, Juliana S. ^[1] ; Vilamaior, Patricia S. L. ^[2] ; Felisbino, Sergio L. ^{[3, 1]} ; Carvalho, Hernandes F. ^[1] ; Taboga, Sebastiao R. ^{[1, 2]}

Affiliation

^[1] State Univ Campinas UNICAMP, Inst Biol, Dept Struct & Funct Biol, Campinas - Brazil

^[2] Sao Paulo State Univ UNESP, Dept Biol Sci, Lab Microscopy & Microanal, Cristovao Colombo St 2265, Sao Jose Do Rio Preto, SP - Brazil

^[3] Sao Paulo State Univ UNESP, Inst Biosci, Botucatu, SP - Brazil

• Document type: Review article
• Source: PROSTATE; v. 81, n. 13 JUL 2021.
• Web of Science Citations: 0

Abstract

Advances in prostatic stroma studies over the past few decades have demonstrated that the stroma not only supports and nourishes the gland's secretory epithelium but also participates in key aspects of morphogenesis, in the prostate's hormonal metabolism, and in the functionality of the secretory epithelium. Furthermore, the stroma is implicated in the onset and progression of prostate cancer through the formation of the so-called reactive stroma, which corresponds to a tumorigenesis-permissive microenvironment. Prostatic stromal cells are interconnected and exchange paracrine signals among themselves in a gland that is highly sensitive to endocrine hormones. There is a growing body of evidence that telocytes, recently detected interstitial cells that are also present in the prostate, are involved in stromal organization, so that their processes form a network of interconnections with both the epithelium and the other stromal cells. The present review provides an update on the different types of prostate stromal cells, their interrelationships and implications for prostate development, physiology and pathological conditions. (AU)

• FAPESP's process: 18/08945-8 - Prostatic telocytes, smooth muscle cells, myofibroblasts and fibroblasts: origin, interrelationships and transdifferentiation.
• Grantee: Bruno Domingos Azevedo Sanches
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 18/23383-6 - Histopathological repercussions of the endocrine disrupters bisfienol-A and 17-beta-oestradiol on mammary glands and female prostate of the Mongolian Gerbil and their relatioships with the chemically induced carcinogenesis by MNU
• Grantee: Sebastião Roberto Taboga
• Support Opportunities: Regular Research Grants