Cancer Metabostemness and Metabolic Reprogramming via P2X7 Receptor

Autor(es)

Rabelo, Izadora Lorrany Alves ^[1] ; Arnaud-Sampaio, Vanessa Fernandes ^[1] ; Adinolfi, Elena ^[2] ; Ulrich, Henning ^[1] ; Lameu, Claudiana ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-05508000 Sao Paulo - Brazil

^[2] Univ Ferrara, Dept Med Sci, Sect Expt Med, I-44121 Ferrara - Italy

• Tipo de documento: Artigo de Revisão
• Fonte: CELLS; v. 10, n. 7 JUL 2021.
• Citações Web of Science: 0

Resumo

The heterogeneity of tumor cell mass and the plasticity of cancer cell phenotypes in solid tumors allow for the insurgence of resistant and metastatic cells, responsible for cancer patients' clinical management's main challenges. Among several factors that are responsible for increased cancer aggression, metabolic reprogramming is recently emerging as an ultimate cancer hallmark, as it is central for cancer cell survival and self-renewal, metastasis and chemoresistance. The P2X7 receptor, whose expression is upregulated in many solid and hematological malignancies, is also emerging as a good candidate in cancer metabolic reprogramming and the regulation of stem cell proliferation and differentiation. Metabostemness refers to the metabolic reprogramming of cancer cells toward less differentiated (CSCs) cellular states, and we believe that there is a strong correlation between metabostemness and P2X7 receptor functions in oncogenic processes. Here, we summarize important aspects of P2X7 receptor functions in normal and tumor tissues as well as essential aspects of its structure, regulation, pharmacology and its clinical use. Finally, we review current knowledge implicating P2X7 receptor functions in cancer-related molecular pathways, in metabolic reprogramming and in metabostemness. (AU)

• Processo FAPESP: 17/06132-7 - Estudo das isoformas do receptor P2X7 na manutenção de células-tronco cancerígenas e metástase
• Beneficiário: Izadora Lorrany Alves Rabelo
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 15/19128-2 - Mecanismos de metástase de tumores infantis para a medula óssea
• Beneficiário: Claudiana Lameu
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 18/07366-4 - Receptores de purinas e cininas como alvos de estudo e intervenção terapêutica em doenças neurológicas
• Beneficiário: Alexander Henning Ulrich
• Modalidade de apoio: Auxílio à Pesquisa - Temático