| Full text | |
| Author(s): |
Rabelo, Izadora Lorrany Alves
[1]
;
Arnaud-Sampaio, Vanessa Fernandes
[1]
;
Adinolfi, Elena
[2]
;
Ulrich, Henning
[1]
;
Lameu, Claudiana
[1]
Total Authors: 5
|
| Affiliation: | [1] Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-05508000 Sao Paulo - Brazil
[2] Univ Ferrara, Dept Med Sci, Sect Expt Med, I-44121 Ferrara - Italy
Total Affiliations: 2
|
| Document type: | Review article |
| Source: | CELLS; v. 10, n. 7 JUL 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
The heterogeneity of tumor cell mass and the plasticity of cancer cell phenotypes in solid tumors allow for the insurgence of resistant and metastatic cells, responsible for cancer patients' clinical management's main challenges. Among several factors that are responsible for increased cancer aggression, metabolic reprogramming is recently emerging as an ultimate cancer hallmark, as it is central for cancer cell survival and self-renewal, metastasis and chemoresistance. The P2X7 receptor, whose expression is upregulated in many solid and hematological malignancies, is also emerging as a good candidate in cancer metabolic reprogramming and the regulation of stem cell proliferation and differentiation. Metabostemness refers to the metabolic reprogramming of cancer cells toward less differentiated (CSCs) cellular states, and we believe that there is a strong correlation between metabostemness and P2X7 receptor functions in oncogenic processes. Here, we summarize important aspects of P2X7 receptor functions in normal and tumor tissues as well as essential aspects of its structure, regulation, pharmacology and its clinical use. Finally, we review current knowledge implicating P2X7 receptor functions in cancer-related molecular pathways, in metabolic reprogramming and in metabostemness. (AU) | |
| FAPESP's process: | 17/06132-7 - Study of P2X7 receptor isoforms in the maintenance of cancer stem cells and metastasis |
| Grantee: | Izadora Lorrany Alves Rabelo |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 15/19128-2 - Metastasis mechanisms of childhood tumors to bone marrow |
| Grantee: | Claudiana Lameu |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 18/07366-4 - Purine and kinin receptors as targets of study and therapeutic interventions in neurological diseases |
| Grantee: | Alexander Henning Ulrich |
| Support Opportunities: | Research Projects - Thematic Grants |