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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Proliferative diabetic retinopathy treated with intravitreal ranibizumab and photocoagulation directed at ischemic retinal areas-A randomized study

Texto completo
Autor(es):
Toscano, Luiza [1] ; Messias, Andre [1] ; Messias, Katharina [1] ; de Cenco Lopes, Rafaella [1] ; Ribeiro, Jefferson A. Santana [2] ; Scott, Ingrid U. [3, 4] ; Jorge, Rodrigo [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Ribeirao Preto Sch Med, Dept Ophthalmol Otorhinolaryngol & Head & Neck Su, Ribeirao Preto, SP - Brazil
[2] Univ Estado Amazonas, Sch Med, Dept Ophthalmol, Manaus, Amazonas - Brazil
[3] Penn State Coll Med, Dept Ophthalmol, Hershey, PA - USA
[4] Penn State Coll Med, Dept Publ Hlth Sci, Hershey, PA - USA
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: DOCUMENTA OPHTHALMOLOGICA; v. 143, n. 3 AUG 2021.
Citações Web of Science: 0
Resumo

Purpose To compare ETDRS panretinal laser photocoagulation (PRP) combined with intravitreal injection of ranibizumab (IVR) and photocoagulation targeted to ischemic retina (PIR) combined with IVR in patients with proliferative diabetic retinopathy (PDR). Methods PDR patients were randomly assigned to treatment with either PRP + IVR or PIR + IVR. ETRDS Best-corrected visual acuity (BCVA) and central subfield thickness (CSFT) measured on optic-coherence tomography images (OCT-Heidelberg Spectralis) were recorded at baseline and every 4 weeks for one year. Fluorescein leakage area (FLA) from active new vessels was measured every 12 weeks. Full-field ERG was recorded by means of DTL electrodes, following ISCEV standard recommendations, at baseline and after 3 months. Results Twenty-eight eyes completed the study period. At baseline, mean +/- SE BCVA (logMAR) was 0.44 +/- 0.07 and 0.37 +/- 0.08 (P = 0.5030); CSFT (mu m) was 324.0 +/- 20.4 and 330.1 +/- 22.1 (P = 0.8417); and FLA (mm(2)) was 16.10 +/- 4.42 and 9.97 +/- 1.83 (P = 0.2114) for PRP + IVR and PIR + IVR groups, respectively. There were no relevant changes on BCVA or CSFT, but a significant reduction for FLA was observed at all visits compared to baseline for both groups, with no differences between groups. ERG showed at baseline reduced dark-adapted amplitudes, and these changes were also significantly amplified after laser treatment. ROD b-wave amplitude was further reduced in 62 +/- 6% for PRP + IVR and 59 +/- 4% for group PIR + IVR, but with no between-groups significant difference (P = 0.9082). Conclusions PIR + IVR or PRP + IVR are comparable strategies regarding FLA control in PDR and led to similar retinal function impairment, based on ERG changes up to one-year follow-up. (AU)

Processo FAPESP: 13/02169-2 - Panfotocoagulação com mira única (ETDRS) versus panfotocoagulação com miras múltiplas (Pascal) associadas à ranibizumabe intravítreo versus somente ranibizumabe intravítreo para retinopatia diabética proliferativa
Beneficiário:Rafael de Montier Pompeu Barroso
Linha de fomento: Bolsas no Brasil - Doutorado Direto
Processo FAPESP: 12/16265-0 - Função retiniana em retinopatia diabética proliferativa após tratamento com laser de múltiplas miras e Ranibizumabe
Beneficiário:Katharina Vieira Messias
Linha de fomento: Bolsas no Brasil - Pós-Doutorado