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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Proliferative diabetic retinopathy treated with intravitreal ranibizumab and photocoagulation directed at ischemic retinal areas-A randomized study

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Author(s):
Toscano, Luiza [1] ; Messias, Andre [1] ; Messias, Katharina [1] ; de Cenco Lopes, Rafaella [1] ; Ribeiro, Jefferson A. Santana [2] ; Scott, Ingrid U. [3, 4] ; Jorge, Rodrigo [1]
Total Authors: 7
Affiliation:
[1] Ribeirao Preto Sch Med, Dept Ophthalmol Otorhinolaryngol & Head & Neck Su, Ribeirao Preto, SP - Brazil
[2] Univ Estado Amazonas, Sch Med, Dept Ophthalmol, Manaus, Amazonas - Brazil
[3] Penn State Coll Med, Dept Ophthalmol, Hershey, PA - USA
[4] Penn State Coll Med, Dept Publ Hlth Sci, Hershey, PA - USA
Total Affiliations: 4
Document type: Journal article
Source: DOCUMENTA OPHTHALMOLOGICA; v. 143, n. 3 AUG 2021.
Web of Science Citations: 0
Abstract

Purpose To compare ETDRS panretinal laser photocoagulation (PRP) combined with intravitreal injection of ranibizumab (IVR) and photocoagulation targeted to ischemic retina (PIR) combined with IVR in patients with proliferative diabetic retinopathy (PDR). Methods PDR patients were randomly assigned to treatment with either PRP + IVR or PIR + IVR. ETRDS Best-corrected visual acuity (BCVA) and central subfield thickness (CSFT) measured on optic-coherence tomography images (OCT-Heidelberg Spectralis) were recorded at baseline and every 4 weeks for one year. Fluorescein leakage area (FLA) from active new vessels was measured every 12 weeks. Full-field ERG was recorded by means of DTL electrodes, following ISCEV standard recommendations, at baseline and after 3 months. Results Twenty-eight eyes completed the study period. At baseline, mean +/- SE BCVA (logMAR) was 0.44 +/- 0.07 and 0.37 +/- 0.08 (P = 0.5030); CSFT (mu m) was 324.0 +/- 20.4 and 330.1 +/- 22.1 (P = 0.8417); and FLA (mm(2)) was 16.10 +/- 4.42 and 9.97 +/- 1.83 (P = 0.2114) for PRP + IVR and PIR + IVR groups, respectively. There were no relevant changes on BCVA or CSFT, but a significant reduction for FLA was observed at all visits compared to baseline for both groups, with no differences between groups. ERG showed at baseline reduced dark-adapted amplitudes, and these changes were also significantly amplified after laser treatment. ROD b-wave amplitude was further reduced in 62 +/- 6% for PRP + IVR and 59 +/- 4% for group PIR + IVR, but with no between-groups significant difference (P = 0.9082). Conclusions PIR + IVR or PRP + IVR are comparable strategies regarding FLA control in PDR and led to similar retinal function impairment, based on ERG changes up to one-year follow-up. (AU)

FAPESP's process: 13/02169-2 - Intravitreal ranibizumab combined with green diode laser (ETDRS) or pattern scan laser (Pascal) Panretinal Photocoagulation (PRP) combined with intravitreal ranibizumab (IVR) versus only intravitreal ranibizumab for proliferative diabetic retinophaty
Grantee:Rafael de Montier Pompeu Barroso
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 12/16265-0 - Retinal function in different therapies for proliferative diabetic retinopathy
Grantee:Katharina Vieira Messias
Support Opportunities: Scholarships in Brazil - Post-Doctoral