fficacy of a hypolipid diet in patients with primary antiphospholipid syndrome with dyslipidemia: a prospective stud

Autor(es)

Rodrigues, Thays C. R. ^[1] ; de Oliveira Vaz, Camila ^[1] ; Miranda, Eliana C. M. ^[1] ; Pereira, Marcos ^[1] ; da Silva Saraiva, Sabrina ^[1] ; Annichino-Bizzacchi, Joyce Maria ^[1] ; de Moraes Mazetto, Bruna ^[1] ; Orsi, Fernanda A. ^{[1, 2, 3]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Hematol & Hemotherapy Ctr, Campinas, SP - Brazil

^[2] Leiden Univ Med Ctr LUMC, Leiden - Netherlands

^[3] Univ Estadual Campinas, Sch Med Sci, Dept Clin Pathol, R Tessalia Vieira Camargo 126, BR-13083887 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF THROMBOSIS AND THROMBOLYSIS; v. 53, n. 2 AUG 2021.
• Citações Web of Science: 0

Resumo

Although dyslipidemia is associated with poorer prognosis in antiphospholipid syndrome (APS), the management of lipid disorders can be challenging. While statins may increase the bleeding risk associated with anticoagulation, the effectiveness of hypolipid diet (HD) has not yet been established in patients with autoimmune disorders. In this study, we evaluated whether HD is associated with decreases in cholesterol levels in patients with thrombotic primary APS (t-PAPS) and dyslipidemia. Nutritional and lipid profiles were assessed before HD was initiated (baseline) and after 3 and 6 months with HD. A 24-h dietary recall was applied to assess the adherence to the diet. Forty-four patients were included, mean age was 43 years (+/- 12.93) and 65% were female. After HD was started, the intake of carbohydrates, lipids, saturated fats and cholesterol decreased, whereas dietary fiber intake increased. Levels of total cholesterol (TC) and non-high density lipoprotein cholesterol (non-HDL-C) decreased after 3 and 6 months of HD, as compared to baseline (P = 0.007 and P = 0.008). Low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) values did not change during the study period. The mean body mass index (BMI) decreased from 28.4 to 27.8 kg/m(2) after six months of HD (p < 0.0001). In subgroup analysis, the effects of HD were more pronounced in patients with high TC, LDL-C or non-HDL-C levels at baseline and in those without obesity or hypertension. Nutritional intervention is feasible among t-PAPS and could be an alternative therapy to modulate lipid metabolism in this population. (AU)

• Processo FAPESP: 16/14172-6 - Investigação de aspectos fisiopatológicos e novas abordagens terapêuticas em doenças tromboembólicas
• Beneficiário: Joyce Maria Annichino-Bizzacchi
• Modalidade de apoio: Auxílio à Pesquisa - Temático