The Immunometabolic Roles of Various Fatty Acids in Macrophages and Lymphocytes

Autor(es)

Neto, Jose Cesar Rosa ^{[1, 2]} ; Calder, Philip C. ^{[3, 4, 5, 6]} ; Curi, Rui ^[7] ; Newsholme, Philip ^{[8, 9]} ; Sethi, Jaswinder K. ^{[3, 4, 5, 6]} ; Silveira, Loreana S. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biomed Sci, Dept Cell Biol & Dev, Immunometab Res Grp, BR-05508000 Sao Paulo - Brazil

^[2] Univ Sao Paulo, LIM 26, Hosp Clin, BR-01246903 Sao Paulo - Brazil

^[3] Univ Southampton, Fac Med, Sch Human Dev & Hlth, Southampton SO16 6YD, Hants - England

^[4] Univ Southampton, Natl Inst Hlth Res Southampton Biomed Res Ctr, Southampton SO16 6YD, Hants - England

^[5] Univ Hosp Southampton Natl Hlth Serv NHS Fdn Trus, Southampton SO16 6YD, Hants - England

^[6] Univ Southampton, Inst Life Sci, Southampton SO17 1BJ, Hants - England

^[7] Univ Cruzeiro Sul, Interdisciplinary Postgrad Program Hlth Sci, BR-01506000 Sao Paulo - Brazil

^[8] Curtin Univ, Curtin Med Sch, Perth, WA 6102 - Australia

^[9] Curtin Univ, Curtin Hlth Innovat Res Inst, Perth, WA 6102 - Australia

• Tipo de documento: Artigo de Revisão
• Fonte: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 22, n. 16 AUG 2021.
• Citações Web of Science: 0

Resumo

Macrophages and lymphocytes demonstrate metabolic plasticity, which is dependent partly on their state of activation and partly on the availability of various energy yielding and biosynthetic substrates (fatty acids, glucose, and amino acids). These substrates are essential to fuel-based metabolic reprogramming that supports optimal immune function, including the inflammatory response. In this review, we will focus on metabolism in macrophages and lymphocytes and discuss the role of fatty acids in governing the phenotype, activation, and functional status of these important cells. We summarize the current understanding of the pathways of fatty acid metabolism and related mechanisms of action and also explore possible new perspectives in this exciting area of research. (AU)

• Processo FAPESP: 19/09854-9 - O efeito da doxorrubicina sobre o tecido adiposo: elucidando o papel da família dos PPARs
• Beneficiário: José Cesar Rosa Neto
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 19/09679-2 - Caracterização da subpopulação de macrófagos com deleção de PPARgamma em modelo de câncer de mama e a influência do treinamento aeróbio moderado
• Beneficiário: Loreana Sanches Silveira
• Linha de fomento: Bolsas no Brasil - Pós-Doutorado