Acid pH Increases SARS-CoV-2 Infection and the Risk of Death by COVID-19

Autor(es):Mostrar menos -

Jimenez, Leandro ^{[1, 2]} ; Codo, Ana Campos ^[3] ; Sampaio, Vanderson de Souza ^{[4, 5, 6, 7]} ; Oliveira, Antonio E. R. ^[1] ; Kobo Ferreira, Lucas Kaoru ^[1] ; Davanzo, Gustavo Gastao ^[3] ; Monteiro, Lauar de Brito ^[3] ; Virgilio-da-Silva, Joao Victor ^[3] ; Silva Borba, Mayla Gabriela ^[4] ; de Souza, Gabriela Fabiano ^[3] ; Zini, Nathalia ^[8] ; Gandolfi, Flora de Andrade ^[8] ; Muraro, Stefanie Primon ^[3] ; Proenca-Modena, Jose Luiz ^[3] ; Val, Fernando Almeida ^{[4, 5, 7]} ; Melo, Gisely Cardoso ^{[4, 5]} ; Monteiro, Wuelton Marcelo ^{[4, 5]} ; Nogueira, Mauricio Lacerda ^[8] ; Guimaraes Lacerda, Marcus Vinicius ^{[4, 5, 7]} ; Moraes-Vieira, Pedro M. ^{[3, 9, 10]} ; Nakaya, I, Helder

Afiliação do(s) autor(es)

^[1] I, Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo - Brazil

^[2] I, Univ Sao Paulo, Sci Platform Pasteur, Sao Paulo - Brazil

^[3] Univ Estadual Campinas, Inst Biol, Dept Genet Evolut Microbiol & Immunol, Sao Paulo - Brazil

^[4] Fundacao Med Trop Dr Heitor Vieira Dourado, Manaus, Amazonas - Brazil

^[5] Univ Estado Amazonas, Manaus, Amazonas - Brazil

^[6] Fundacao Vigilancia Saude Amazonas, Manaus, Amazonas - Brazil

^[7] Univ Fed Amazonas, Fac Med, Manaus, Amazonas - Brazil

^[8] Fac Med Sao Jose do Rio Preto, Sao Paulo - Brazil

^[9] Univ Estadual Campinas, Obes & Comorbid Res Ctr, Sao Paulo - Brazil

^[10] Univ Estadual Campinas, Expt Med Res Cluster, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN MEDICINE; v. 8, AUG 20 2021.
• Citações Web of Science: 0

Resumo

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can infect a broad range of human tissues by using the host receptor angiotensin-converting enzyme 2 (ACE2). Individuals with comorbidities associated with severe COVID-19 display higher levels of ACE2 in the lungs compared to those without comorbidities, and conditions such as cell stress, elevated glucose levels and hypoxia may also increase the expression of ACE2. Here, we showed that patients with Barrett's esophagus (BE) have a higher expression of ACE2 in BE tissues compared to normal squamous esophagus, and that the lower pH associated with BE may drive this increase in expression. Human primary monocytes cultured in reduced pH displayed increased ACE2 expression and higher viral load upon SARS-CoV-2 infection. We also showed in two independent cohorts of 1,357 COVID-19 patients that previous use of proton pump inhibitors is associated with 2- to 3-fold higher risk of death compared to those not using the drugs. Our work suggests that pH has a great influence on SARS-CoV-2 Infection and COVID-19 severity. (AU)

• Processo FAPESP: 18/14933-2 - Biologia integrativa aplicada à saúde humana
• Beneficiário: Helder Takashi Imoto Nakaya
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores - Fase 2
• Processo FAPESP: 20/04836-0 - Estudo clínico e epidemiológico de SARS-CoV-2 em uma coorte prospectiva populacional e hospitalar em São José do Rio Preto, São Paulo, Brasil, durante pandemia de 2020
• Beneficiário: Maurício Lacerda Nogueira
• Modalidade de apoio: Auxílio à Pesquisa - Regular