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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Acid pH Increases SARS-CoV-2 Infection and the Risk of Death by COVID-19

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Author(s):
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Jimenez, Leandro [1, 2] ; Codo, Ana Campos [3] ; Sampaio, Vanderson de Souza [4, 5, 6, 7] ; Oliveira, Antonio E. R. [1] ; Kobo Ferreira, Lucas Kaoru [1] ; Davanzo, Gustavo Gastao [3] ; Monteiro, Lauar de Brito [3] ; Virgilio-da-Silva, Joao Victor [3] ; Silva Borba, Mayla Gabriela [4] ; de Souza, Gabriela Fabiano [3] ; Zini, Nathalia [8] ; Gandolfi, Flora de Andrade [8] ; Muraro, Stefanie Primon [3] ; Proenca-Modena, Jose Luiz [3] ; Val, Fernando Almeida [4, 5, 7] ; Melo, Gisely Cardoso [4, 5] ; Monteiro, Wuelton Marcelo [4, 5] ; Nogueira, Mauricio Lacerda [8] ; Guimaraes Lacerda, Marcus Vinicius [4, 5, 7] ; Moraes-Vieira, Pedro M. [3, 9, 10] ; Nakaya, I, Helder
Total Authors: 21
Affiliation:
[1] I, Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo - Brazil
[2] I, Univ Sao Paulo, Sci Platform Pasteur, Sao Paulo - Brazil
[3] Univ Estadual Campinas, Inst Biol, Dept Genet Evolut Microbiol & Immunol, Sao Paulo - Brazil
[4] Fundacao Med Trop Dr Heitor Vieira Dourado, Manaus, Amazonas - Brazil
[5] Univ Estado Amazonas, Manaus, Amazonas - Brazil
[6] Fundacao Vigilancia Saude Amazonas, Manaus, Amazonas - Brazil
[7] Univ Fed Amazonas, Fac Med, Manaus, Amazonas - Brazil
[8] Fac Med Sao Jose do Rio Preto, Sao Paulo - Brazil
[9] Univ Estadual Campinas, Obes & Comorbid Res Ctr, Sao Paulo - Brazil
[10] Univ Estadual Campinas, Expt Med Res Cluster, Sao Paulo - Brazil
Total Affiliations: 10
Document type: Journal article
Source: FRONTIERS IN MEDICINE; v. 8, AUG 20 2021.
Web of Science Citations: 0
Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can infect a broad range of human tissues by using the host receptor angiotensin-converting enzyme 2 (ACE2). Individuals with comorbidities associated with severe COVID-19 display higher levels of ACE2 in the lungs compared to those without comorbidities, and conditions such as cell stress, elevated glucose levels and hypoxia may also increase the expression of ACE2. Here, we showed that patients with Barrett's esophagus (BE) have a higher expression of ACE2 in BE tissues compared to normal squamous esophagus, and that the lower pH associated with BE may drive this increase in expression. Human primary monocytes cultured in reduced pH displayed increased ACE2 expression and higher viral load upon SARS-CoV-2 infection. We also showed in two independent cohorts of 1,357 COVID-19 patients that previous use of proton pump inhibitors is associated with 2- to 3-fold higher risk of death compared to those not using the drugs. Our work suggests that pH has a great influence on SARS-CoV-2 Infection and COVID-19 severity. (AU)

FAPESP's process: 18/14933-2 - Integrative biology applied to human health
Grantee:Helder Takashi Imoto Nakaya
Support type: Research Grants - Young Investigators Grants - Phase 2
FAPESP's process: 20/04836-0 - Clinical and epidemiological study of SARS-CoV-2 in a prospective population and hospitalar cohorts in São José do Rio Preto, SP, Brazil in 2020
Grantee:Maurício Lacerda Nogueira
Support type: Regular Research Grants