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Exploring miniaturized sample preparation approaches combined with LC-QToF-MS for the analysis of sulfonamide antibiotic residues in meat-and/or egg-based baby foods

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Autor(es):
Petrarca, Mateus Henrique [1] ; de Campos Braga, Patricia Aparecida [1] ; Reyes Reyes, Felix Guillermo [1] ; Arisseto Bragotto, Adriana Pavesi [1]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, UNICAMP, Dept Food Sci, Sch Food Engn, Rua Monteiro Lobato 80, BR-13083862 Campinas, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: Food Chemistry; v. 366, JAN 1 2022.
Citações Web of Science: 0
Resumo

Miniaturized and simplified sample preparation methods with reduced consumption of chemicals and nonhalogenated solvents are presented for the determination of 12 sulfonamides in baby foods. Hydrophilic interaction liquid chromatography coupled to quadrupole time-of-flight mass spectrometry was used for the identification and quantification of the compounds based on the acquisition of full spectrum at high resolution with accurate mass for precursor and its fragment ions. Three miniaturized protocols based on QuEChERS, salting-out assisted liquid-liquid extraction or low-temperature cleanup were evaluated regarding the extraction efficiency and removal capability of matrix co-extractives. All approaches achieved satisfactory recoveries (70.0-120.0%); however, the miniaturized QuEChERS distinguished by lower co-extractives content in the final extract providing lower matrix effects. Thus, the performance characteristics of the miniaturized QuEChERS were established using different matrices: beef-, egg yolk- and vegetable-based baby food or chicken- and vegetable-based baby food, in compliance with the Codex Alimentarius Commission guidelines. The target compounds were investigated in 30 commercial baby foods. (AU)

Processo FAPESP: 04/09149-8 - Espectrometria de massas em ciência e tecnologia de alimentos
Beneficiário:Felix Guillermo Reyes Reyes
Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários