Tumor-Derived Extracellular Vesicles: Modulation of Cellular Functional Dynamics in Tumor Microenvironment and Its Clinical Implications

Autor(es)

Santos, Nathalia Leal ^[1] ; Bustos, Silvina Odete ^[1] ; Bhatt, Darshak ^{[2, 1]} ; Chammas, Roger ^[1] ; Andrade, Luciana Nogueira de Sousa ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Canc Estado Sao Paulo, Hosp Clin, Ctr Translat Res Oncol, Fac Med, Sao Paulo - Brazil

^[2] Univ Groningen, Univ Med Ctr Groningen, Dept Med Microbiol & Infect Prevent, Groningen - Netherlands

• Tipo de documento: Artigo de Revisão
• Fonte: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY; v. 9, AUG 31 2021.
• Citações Web of Science: 0

Resumo

Cancer can be described as a dynamic disease formed by malignant and stromal cells. The cellular interaction between these components in the tumor microenvironment (TME) dictates the development of the disease and can be mediated by extracellular vesicles secreted by tumor cells (TEVs). In this review, we summarize emerging findings about how TEVs modify important aspects of the disease like continuous tumor growth, induction of angiogenesis and metastasis establishment. We also discuss how these nanostructures can educate the immune infiltrating cells to generate an immunosuppressive environment that favors tumor progression. Furthermore, we offer our perspective on the path TEVs interfere in cancer treatment response and promote tumor recurrence, highlighting the need to understand the underlying mechanisms controlling TEVs secretion and cargo sorting. In addition, we discuss the clinical potential of TEVs as markers of cell state transitions including the acquisition of a treatment-resistant phenotype, and their potential as therapeutic targets for interventions such as the use of extracellular vesicle (EV) inhibitors to block their pro-tumoral activities. Some of the technical challenges for TEVs research and clinical use are also presented.</p> (AU)

• Processo FAPESP: 19/07278-0 - Efeito da super-expressão do miR-195 na carga de microRNAs presentes em vesículas extracelulares secretadas por células de melanoma humano e na regulação da sensibilidade ao tratamento alvo-dirigido via transferência horizontal de informação
• Beneficiário: Nathalia Leal Santos
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 20/09176-8 - Avaliação de resposta à terapia viral oncolítica em tumores imunogênicos: o papel de vesículas extracelulares no desfecho terapêutico
• Beneficiário: Luciana Nogueira de Sousa Andrade
• Modalidade de apoio: Auxílio à Pesquisa - Regular