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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Tumor-Derived Extracellular Vesicles: Modulation of Cellular Functional Dynamics in Tumor Microenvironment and Its Clinical Implications

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Author(s):
Santos, Nathalia Leal [1] ; Bustos, Silvina Odete [1] ; Bhatt, Darshak [2, 1] ; Chammas, Roger [1] ; Andrade, Luciana Nogueira de Sousa [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Inst Canc Estado Sao Paulo, Hosp Clin, Ctr Translat Res Oncol, Fac Med, Sao Paulo - Brazil
[2] Univ Groningen, Univ Med Ctr Groningen, Dept Med Microbiol & Infect Prevent, Groningen - Netherlands
Total Affiliations: 2
Document type: Review article
Source: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY; v. 9, AUG 31 2021.
Web of Science Citations: 0
Abstract

Cancer can be described as a dynamic disease formed by malignant and stromal cells. The cellular interaction between these components in the tumor microenvironment (TME) dictates the development of the disease and can be mediated by extracellular vesicles secreted by tumor cells (TEVs). In this review, we summarize emerging findings about how TEVs modify important aspects of the disease like continuous tumor growth, induction of angiogenesis and metastasis establishment. We also discuss how these nanostructures can educate the immune infiltrating cells to generate an immunosuppressive environment that favors tumor progression. Furthermore, we offer our perspective on the path TEVs interfere in cancer treatment response and promote tumor recurrence, highlighting the need to understand the underlying mechanisms controlling TEVs secretion and cargo sorting. In addition, we discuss the clinical potential of TEVs as markers of cell state transitions including the acquisition of a treatment-resistant phenotype, and their potential as therapeutic targets for interventions such as the use of extracellular vesicle (EV) inhibitors to block their pro-tumoral activities. Some of the technical challenges for TEVs research and clinical use are also presented.</p> (AU)

FAPESP's process: 19/07278-0 - Effect of miR-195 superexpression in the cargo of microRNAs present in extracellular vesicles secreted by human melanoma cells and in the regulation of sensibility to target-therapy through horizontal transfer of information
Grantee:Nathalia Leal Santos
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 20/09176-8 - Assessment of response to oncolytic viral therapy in immunogenic tumors: the role of extracellular vesicles in the therapeutic outcome
Grantee:Luciana Nogueira de Sousa Andrade
Support Opportunities: Regular Research Grants