Soluble Carrier Transporters and Mitochondria in the Immunometabolic Regulation of Macrophages

Autor(es)

Lima-Silva, Lincon Felipe ^{[1, 2]} ; Lee, Jennifer ^[3] ; Moraes-Vieira, Pedro M. ^{[4, 5, 1]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Inst Biol, Dept Genet Evolut Microbiol & Immunol, Lab Immunometab, Campinas - Brazil

^[2] Univ Sao Paulo, Inst Biomed Sci, Post Grad Program Immunol, Sao Paulo - Brazil

^[3] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Med, Div Endocrinol Diabet & Metab, Boston, MA 02115 - USA

^[4] Univ Estadual Campinas, Expt Med Res Cluster EMRC, Campinas - Brazil

^[5] Univ Estadual Campinas, Obes & Comorbid Res Ctr OCRC, Campinas - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Antioxidants & Redox Signaling; JAN 2022.
• Citações Web of Science: 0

Resumo

Significance: Immunometabolic regulation of macrophages is a growing area of research across many fields. Here, we review the contribution of solute carriers (SLCs) in regulating macrophage metabolism. We also highlight key mechanisms that regulate SLC function, their effects on mitochondrial activity, and how these intracellular activities contribute to macrophage fitness in health and disease.Recent Advances: SLCs serve as a major drug absorption pathway and represent a novel category of therapeutic drug targets. SLC dynamics affect cellular nutritional sensors, such as AMP-activated protein kinase and mammalian target of rapamycin, and consequently alter the cellular metabolism and mitochondrial dynamics within macrophages to adapt to a new functional phenotype.Critical Issues: SLC function affects macrophage phenotype, but their mechanisms of action and how their functions contribute to host health remain incompletely defined.Future Directions: Few studies focus on the impact of solute transporters on macrophage function. Identifying which SLCs are present in macrophages and determining their functional roles may reveal novel therapeutic targets with which to treat metabolic and inflammatory diseases. (AU)

• Processo FAPESP: 13/07607-8 - CMPO - Centro Multidisciplinar de Pesquisa em Obesidade e Doenças Associadas
• Beneficiário: Licio Augusto Velloso
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 19/19435-3 - Papel de danos no DNA e função mitocondrial em envelhecimento vascular, imune e neurológico (DNA MoVINg)
• Beneficiário: Carlos Frederico Martins Menck
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 19/25973-8 - Mitoimunidade: estudo da adaptação da mitocôndria em estados fisiológicos e patológicos
• Beneficiário: Pedro Manoel Mendes de Moraes Vieira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/15626-8 - Imunometabolismo em macrófagos e em linfócitos T nas doenças inflamatórias e metabólicas
• Beneficiário: Pedro Manoel Mendes de Moraes Vieira
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores