From skeletal muscle damage and regeneration to the hypertrophy induced by exercise: what is the role of different macrophage subsets?

Autor(es)

Araujo Minari, Andre Luis ^{[1, 2]} ; Thomatieli-Santos, V, Ronaldo

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, Presidente Prudente - Brazil

^[2] V, Univ Fed Sao Paulo, Psicobiol, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY; v. 322, n. 1, p. R41-R54, JAN 2022.
• Citações Web of Science: 0

Resumo

Macrophages are one of the top players when considering immune cells involved with tissue homeostasis. Recently, increasing evidence has demonstrated that macrophages could also present two major subsets during tissue healing: proliferative macrophages (M1-like), which are responsible for increasing myogenic cell proliferation, and restorative macrophages (M2-like), which are involved in the end of the mature muscle myogenesis. The participation and characterization of these macrophage subsets are critical during myogenesis to understand the inflammatory role of macrophages during muscle recovery and to create supportive strategies that can improve mass muscle maintenance. Indeed, most of our knowledge about macrophage subsets comes from skeletal muscle damage protocols, and we still do not know how these subsets can contribute to skeletal muscle adaptation. Thus, this narrative review aims to collect and discuss studies demonstrating the involvement of different macrophage subsets during the skeletal muscle damage/regeneration process, show-casing an essential role of these macrophage subsets during muscle adaptation induced by acute and chronic exercise programs. (AU)

• Processo FAPESP: 19/05797-0 - Papel dos subtipos de macrófagos na secreção de fatores de crescimento e ativação de vias associadas a hipertrofia muscular em camundongos PPAR-± knockout após lesão induzida pelo exercício físico agudo
• Beneficiário: Andre Luis Araujo Minari
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 18/19678-0 - Sensores energéticos e polarização de monócitos / macrófagos M1 e M2: potencial influência do tecido adiposo visceral e aptidão aeróbia
• Beneficiário: Fábio Santos de Lira
• Modalidade de apoio: Auxílio à Pesquisa - Regular