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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

From skeletal muscle damage and regeneration to the hypertrophy induced by exercise: what is the role of different macrophage subsets?

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Author(s):
Araujo Minari, Andre Luis [1, 2] ; Thomatieli-Santos, V, Ronaldo
Total Authors: 2
Affiliation:
[1] Univ Estadual Paulista, Presidente Prudente - Brazil
[2] V, Univ Fed Sao Paulo, Psicobiol, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY; v. 322, n. 1, p. R41-R54, JAN 2022.
Web of Science Citations: 0
Abstract

Macrophages are one of the top players when considering immune cells involved with tissue homeostasis. Recently, increasing evidence has demonstrated that macrophages could also present two major subsets during tissue healing: proliferative macrophages (M1-like), which are responsible for increasing myogenic cell proliferation, and restorative macrophages (M2-like), which are involved in the end of the mature muscle myogenesis. The participation and characterization of these macrophage subsets are critical during myogenesis to understand the inflammatory role of macrophages during muscle recovery and to create supportive strategies that can improve mass muscle maintenance. Indeed, most of our knowledge about macrophage subsets comes from skeletal muscle damage protocols, and we still do not know how these subsets can contribute to skeletal muscle adaptation. Thus, this narrative review aims to collect and discuss studies demonstrating the involvement of different macrophage subsets during the skeletal muscle damage/regeneration process, show-casing an essential role of these macrophage subsets during muscle adaptation induced by acute and chronic exercise programs. (AU)

FAPESP's process: 19/05797-0 - Role of macrophage subtypes in secretion of growth factors and pathway activation associated with muscle hypertrophy in PPAR-± knockout mice after exercise induced muscle damage
Grantee:Andre Luis Araujo Minari
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 18/19678-0 - Energetic sensors and polarization of monocytes / macrophages M1 and M2: potential influence of visceral adipose tissue and aerobic fitness
Grantee:Fábio Santos de Lira
Support Opportunities: Regular Research Grants