| Texto completo | |
| Autor(es): |
Quintanilha, Bruna J.
[1, 2]
;
Chaves, Daniela F. S.
[3]
;
Brasili, Elisa
[4]
;
Correa, Telma A. F.
[2, 3]
;
Capetini, Vinicius Cooper
[1, 2]
;
Ferreira, Frederico Moraes
[5]
;
Castro, Inar A.
[2, 3]
;
Hassimotto, Neuza M. A.
[2, 3]
;
Rogero, Marcelo M.
[1, 2]
;
Lajolo, Franco M.
[2, 3]
Número total de Autores: 10
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo - Brazil
[2] CEPID FAPESP Res Innovat & Disseminat Ctr Sao Pau, Food Res Ctr FoRC, Sao Paulo - Brazil
[3] Univ Sao Paulo, Dept Food Sci & Expt Nutr, Sch Pharmaceut Sci, Sao Paulo - Brazil
[4] Sapienza Univ Rome, Dept Environm Biol, Rome - Italy
[5] Univ Sao Paulo, Div Pathol, Sch Med, Sao Paulo - Brazil
Número total de Afiliações: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | CLINICAL NUTRITION ESPEN; v. 47, p. 240-245, FEB 2022. |
| Citações Web of Science: | 0 |
| Resumo | |
Background \& aims: The intake of high-fat, high-carbohydrate (HFHC) meals is associated with an increased risk of type 2 diabetes. There is evidence that the association of orange juice to a HFHC meal can modulate the expression of microRNAs (miRNAs) linked to pancreatic beta-cell function such as miR-375. We evaluated the effect of a commercial orange juice intake with HFHC meal on plasma miRNAs expression in twelve healthy subjects in a crossover design study. Methods: Subjects ingested water, orange juice, or an isocaloric beverage along with a 1037 kcal HFHC meal. Blood glucose and miRNAs were evaluated at baseline and 1, 3, and 5 h after the intake. Results: The area under the curve (AUC) for glycemia after ingestion of HFHC + orange juice did not differ from ingestion of HPHC + glucose or HFHC + water. However, the AUC was higher in HFHC meal + glucose compared to HFHC meal + water (p = 0.034). Glucose and insulin concentrations were significantly higher in HFHC meal + glucose group after 1 h, when compared with other groups and times (p < 0.001). There was an increase in plasma miR-375 expression after 3 h of ingestion of HFHC + orange juice versus water (p = 0.026), and a decrease in plasma miR-205-5p expression after HFHC meal + glucose versus water (p = 0.023). Conclusions: A single HFHC meal + orange juice modulated plasma miR-375 expression, which is a biomarker of pancreatic beta-cell function, and contributed to preventing hyperglycemia. (C) 2021 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. (AU) | |
| Processo FAPESP: | 14/22864-0 - Identificação de biomarcadores de ingestão de polifenóis oriundos da dieta usando abordagens metabolômica e proteômica |
| Beneficiário: | Daniela Fojo Seixas Chaves |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 13/07914-8 - FoRC - Centro de Pesquisa em Alimentos |
| Beneficiário: | Bernadette Dora Gombossy de Melo Franco |
| Modalidade de apoio: | Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs |