Relaxin-2 during pregnancy according to glycemia, continence status, and pelvic floor muscle function

Autor(es)

Prudencio, Caroline Baldini ; Nunes, Sthefanie Kenickel ; Pinheiro, Fabiane Affonso ; Sartorao Filho, Carlos Isaias ; Antonio, Flavia Ignacio ; de Aquino Nava, Guilherme Thomaz ; Cunha Rudge, Marilza Vieira ; Pascon Barbosa, Angelica Mercia ; Diamater Study Grp

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL UROGYNECOLOGY JOURNAL; v. N/A, p. 9-pg., 2022-06-03.

Resumo

Introduction and hypothesis To investigate relaxin-2 concentration comparing gestational diabetes mellitus (GDM) and non-GDM patients during pregnancy according to urinary incontinence (UI) and pelvic function status. Methods This is a cross-sectional study evaluating 282 pregnant women from 24 weeks of gestation. The participants were divided into two groups, non-GDM and GDM, according to American Diabetes Association's diabetes mellitus gestational threshold. In addition, according to subanalysis, both groups were subdivided according to the presence of pregnancy-specific urinary incontinence: non-GDM continent, non-GDM incontinent, GDM continent, and GDM incontinent. All participants filled in questionnaires on clinical, obstetric, and urinary continence status (International Consultation on Incontinence Questionnaire-Short Form, ICIQ-SF, and Incontinence Severity Index, ISI), followed by pelvic floor muscle evaluation by the PERFECT scheme in which strength, endurance, and speed of contractions were evaluated. Results Serum relaxin-2 concentrations were significantly lower in pregnant women with pregnancy-specific urinary incontinence in both non-GDM and GDM patients, but GDM showed the lowest concentration. In addition, the stratification of the groups according to pelvic floor muscle strength showed that pregnant patients with GDM and modified Oxford scale 0-2 had significantly lower levels than those who were non-GDM and GDM with Modified Oxford Scale 3-5. Relaxin-2 level was much lower in GDM incontinent pregnant women with MOS 0-2 compared to the other three groups. Conclusions Lower relaxin-2 concentration was associated with the presence of pregnancy-specific urinary incontinence, but the combination of GDM, pregnancy-specific urinary incontinence, and lower levels of pelvic floor strength led to lower levels of relaxin-2 compared to the other three groups. (AU)

• Processo FAPESP: 21/10665-6 - Efetividade do treino do assoalho pélvico em meio aquático na função muscular e incontinência urinária específica da gestação em mulheres com Diabetes Gestacional: estudo de viabilidade para ensaio clínico controlado randomizado
• Beneficiário: Caroline Baldini Prudencio
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 16/01743-5 - Coorte da tríade gestacional: hiperglicemia, incontinência urinária e perfil clínico, molecular e ômico da miopatia hiperglicêmica na predição de incontinência e disfunção muscular e pesquisa translacional com biodevice para regeneração muscular em ratas
• Beneficiário: Marilza Vieira Cunha Rudge
• Modalidade de apoio: Auxílio à Pesquisa - Temático