Resistance training variable manipulations are less relevant than intrinsic biology in affecting muscle fiber hypertrophy

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Angleri, Vitor ; Damas, Felipe ; Phillips, Stuart M. ; Selistre-de-Araujo, Heloisa Sobreiro ; Cornachione, Anabelle Silva ; Stotzer, Uliana Sbeguen ; Santanielo, Natalia ; Soligon, Samuel Domingos ; Costa, Luiz Augusto Riani ; Lixandrao, Manoel Emilio ; Conceicao, Miguel Soares ; Vechin, Felipe Cassaro ; Ugrinowitsch, Carlos ; Libardi, Cleiton Augusto

• Tipo de documento: Artigo Científico
• Fonte: SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS; v. 32, n. 5, p. 12-pg., 2022-02-07.

Resumo

We aimed to investigate whether muscle fiber cross-sectional area (fCSA) and associated molecular processes could be differently affected at the group and individual level by manipulating resistance training (RT) variables. Twenty resistance-trained subjects had each leg randomly allocated to either a standard RT (RT-CON: without specific variables manipulations) or a variable RT (RT-VAR: manipulation of load, volume, muscle action, and rest interval at each RT session). Muscle fCSA, satellite cell (SC) pool, myonuclei content, and gene expression were assessed before and after training (chronic effect). Gene expression was assessed 24 h after the last training session (acute effect). RT-CON and RT-VAR increased fCSA and myonuclei domain in type I and II fibers after training (p < 0.05). SC and myonuclei content did not change for both conditions (p > 0.05). Pax-7, MyoD, MMP-2 and COL3A1 (chronic) and MGF, Pax-7, and MMP-9 (acute) increased similar for RT-CON and RT-VAR (p < 0.05). The increase in acute MyoG expression was significantly higher for the RT-VAR than RT-CON (p < 0.05). We found significant correlation between RT-CON and RT-VAR for the fCSA changes (r = 0.89). fCSA changes were also correlated to satellite cells (r = 0.42) and myonuclei (r = 0.50) changes. Heatmap analyses showed coupled changes in fCSA, SC, and myonuclei responses at the individual level, regardless of the RT protocol. The high between and low within-subject variability regardless of RT protocol suggests that the intrinsic biological factors seem to be more important to explain the magnitude of fCSA gains in resistance-trained subjects. (AU)

• Processo FAPESP: 17/05331-6 - Hipertrofia muscular: variáveis do treinamento de força versus individualidade biológica humana.
• Beneficiário: Vitor Angleri
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 17/04299-1 - Individualidade biológica humana versus variáveis do treinamento de força: o que realmente importa para a hipertrofia muscular?
• Beneficiário: Cleiton Augusto Libardi
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/13064-0 - Respostas individuais da síntese de proteína muscular à modulação de variáveis de treinamento de força
• Beneficiário: Felipe Romano Damas Nogueira
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
• Processo FAPESP: 16/22635-6 - Efeito do volume de treinamento de força sobre a variabilidade da hipertrofia muscular em idosos
• Beneficiário: Manoel Emílio Lixandrão
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 16/24259-1 - Individualidade biológica humana versus variáveis do treinamento de força: o que realmente importa para a hipertrofia muscular?
• Beneficiário: Felipe Romano Damas Nogueira
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/07104-6 - Efeitos do exercício excêntrico na reabilitação do músculo esquelético de camundongos mdx após longo período de treinamento: avaliações morfológica, funcional e molecular
• Beneficiário: Anabelle Silva Cornachione
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores