Genetic, Cellular and Molecular Aspects involved in Apical Periodontitis

Autor(es)

Igor Bassi Ferreira Petean ^[1] ; Alice Corrêa Silva-Sousa ^[2] ; Tamara Justiniano Cronenbold ^[3] ; Jardel Francisco Mazzi-Chaves ^[4] ; Lea Assed Bezerra da Silva ^[5] ; Raquel Assed Bezerra Segato ^[6] ; Guilherme Assed Piedade de Castro ^[7] ; Erika Calvano Kuchler ; Francisco Wanderley Garcia Paula-Silva ^[9] ; Manoel Damião Sousa-Neto ^[10]

Afiliação do(s) autor(es)

^[1] University of São Paulo. School of Dentistry of Ribeirão Preto. Department of Restorative Dentistry - Brasil

^[2] University of São Paulo. School of Dentistry of Ribeirão Preto. Department of Restorative Dentistry - Brasil

^[3] University of São Paulo. School of Dentistry of Ribeirão Preto. Department of Restorative Dentistry - Brasil

^[4] University of São Paulo. School of Dentistry of Ribeirão Preto. Department of Restorative Dentistry - Brasil

^[5] University of São Paulo. School of Dentistry of Ribeirão Preto. Department of Pediatric Dentistry - Brasil

^[6] University of São Paulo. School of Dentistry of Ribeirão Preto. Department of Pediatric Dentistry - Brasil

^[7] University of São Paulo. School of Dentistry of Ribeirão Preto. Department of Restorative Dentistry - Brasil

^[9] University of São Paulo. School of Dentistry of Ribeirão Preto. Department of Pediatric Dentistry - Brasil

^[10] University of São Paulo. School of Dentistry of Ribeirão Preto. Department of Restorative Dentistry - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Dental Journal; v. 33, n. 4, p. 1-11, 2022-08-26.

Resumo

Abstract The development, establishment and repair of apical periodontitis (AP) is dependent of several factors, which include host susceptibility, microbial infection, immune response, quality of root canal treatment and organism's ability to repair. The understanding of genetic contributions to the risk of developing AP and presenting persistent AP has been extensively explored in modern Endodontics. Thus, this article aims to provide a review of the literature regarding the biochemical mediators involved in immune response signaling, osteoclastogenesis and bone neoformation, as the genetic components involved in the development and repair of AP. A narrative review of the literature was performed through a PUBMED/MEDLINE search and a hand search of the major AP textbooks. The knowledge regarding the cells, receptors and molecules involved in the host's immune-inflammatory response during the progression of AP added to the knowledge of bone biology allows the identification of factors inherent to the host that can interfere both in the progression and in the repair of these lesions. The main outcomes of studies evaluated in the review that investigated the correlation between genetic polymorphisms and AP in the last five years, demonstrate that genetic factors of the individual are involved in the success of root canal treatment. The discussion of this review gives subsides that may help to glimpse the development of new therapies based on the identification of therapeutic targets and the development of materials and techniques aimed at acting at the molecular level for clinical, radiographic and histological success of root canal treatment. (AU)

• Processo FAPESP: 13/09595-7 - Papel dos inibidores seletivo e não-seletivo da enzima ciclooxigenase-2 e da enzima 5-lipoxigenase na osteoclastogênese no tratamento da lesão periapical experimental
• Beneficiário: Igor Bassi Ferreira Petean
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 15/06866-5 - Avaliação do papel do estrógeno no desenvolvimento dentofacial
• Beneficiário: Erika Calvano Kuchler
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 10/17611-4 - Mecanismos envolvidos na modulação da via 5-lipoxigenase na lesão periapical experimentalmente induzida
• Beneficiário: Francisco Wanderley Garcia de Paula e Silva
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores