Persistent or new symptoms 1 year after a single high dose of vitamin D-3 in patients with moderate to severe COVID-19

Autor(es)

Fernandes, Alan L. L. ; Sales, Lucas P. P. ; Santos, Mayara D. D. ; Caparbo, Valeria F. F. ; Murai, Igor H. H. ; Pereira, Rosa M. R.

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN NUTRITION; v. 9, p. 10-pg., 2022-09-13.

Resumo

Purpose: The aim of this study was to investigate the reported persistent or new symptoms 1 year after a single dose of 200,000 IU of vitamin D-3 and hospitalization in patients with moderate to severe COVID-19. Methods: This is a post-hoc, exploratory analysis from a multicenter, double-blind, placebo-controlled, randomized clinical trial from two hospitals in Sao Paulo, Brazil, registered in NCT04449718. Discharged patients were followed for up to 1 year and evaluated by telephone interviews at 6 and 12 months. The primary and secondary outcomes were previously published. These post-hoc exploratory secondary outcomes are the persistent or new symptoms and quality of life (QoL) at the post-viral stage of COVID-19. Generalized estimating equations (GEE) for repeated measures with Bonferroni's adjustment were used for testing outcomes.ResultsBetween 2 June and 27 August 2020, we randomized 240 patients of which 144 were included in this study [the vitamin D-3 (n = 71) or placebo (n = 73) group]. The mean (SD) age was 54.3 (13.1) years, and body mass index (BMI) was 32.4 (6.5) kg/m(2). Fever demonstrated a significant main effect of time (P < 0.001) with a reduction from baseline to 6 (52-0) and 12 months (52-0). No significant differences between groups were observed for fever, cough, fatigue, fever, myalgia, joint pain, runny nose, nasal congestion, sore throat, hypertension, diabetes, cardiovascular disease, rheumatic disease, asthma, chronic obstructive pulmonary, chronic kidney disease, QoL, and new or persistent symptoms up to 1-year of follow-up.ConclusionThe findings do not support the use of 200,000 IU of vitamin D-3 compared to placebo for the management of persistence or new symptoms, and QoL reported by moderate to severe patients after hospitalization for COVID-19. (AU)

• Processo FAPESP: 20/11102-2 - Suplementação com vitamina D em pacientes com COVID-19: ensaio clínico, randomizado, duplo-cego e controlado por placebo
• Beneficiário: Alan Lins Fernandes
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 19/24782-4 - Comparação dos mecanismos de perda óssea em pacientes submetidos à derivação gástrica em Y de Roux ou gastrectomia vertical
• Beneficiário: Igor Hisashi Murai
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 20/07098-0 - Impacto da Obesidade, Sarcopenia, e Obesidade Sarcopênica nos marcadores de saúde e qualidade de vida de idosas com síndrome de fragilidade não institucionalizadas
• Beneficiário: Alan Lins Fernandes
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 20/05752-4 - Suplementação com vitamina D em pacientes com COVID-19: ensaio clínico, randomizado, duplo-cego e controlado por placebo
• Beneficiário: Rosa Maria Rodrigues Pereira
• Modalidade de apoio: Auxílio à Pesquisa - Regular