| Texto completo | |
| Autor(es): Mostrar menos - |
Siekman, Sterre L.
;
Pongracz, Tamas
;
Wang, Wenjun
;
Nouta, Jan
;
Kremsner, Peter G.
;
da Silva-Neto, Pedro Vieira
;
Esen, Meral
;
Kreidenweiss, Andrea
;
Held, Jana
;
Trape, Atila Alexandre
;
Fendel, Rolf
;
de Miranda Santos, Isabel Kinney Ferreira
;
Wuhrer, Manfred
Número total de Autores: 13
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| Tipo de documento: | Artigo Científico |
| Fonte: | FRONTIERS IN IMMUNOLOGY; v. 13, p. 13-pg., 2022-10-18. |
| Resumo | |
Immunoglobulin G (IgG) antibodies play an important role in the immune response against viruses such as SARS-CoV-2. As the effector functions of IgG are modulated by N-glycosylation of the Fc region, the structure and possible function of the IgG N-glycome has been under investigation in relation to divergent COVID-19 disease courses. Through LC-MS analysis we studied both total IgG1 and spike protein-specific IgG1 Fc glycosylation of 129 German and 163 Brazilian COVID-19 patients representing diverse patient populations. We found that hospitalized COVID-19 patients displayed decreased levels of total IgG1 bisection and galactosylation and lowered anti-S IgG1 fucosylation and bisection as compared to mild outpatients. Anti-S IgG1 glycosylation was dynamic over the disease course and both anti-S and total IgG1 glycosylation were correlated to inflammatory markers. Further research is needed to dissect the possible role of altered IgG glycosylation profiles in (dys)regulating the immune response in COVID-19. (AU) | |
| Processo FAPESP: | 20/05207-6 - Avaliação prospectiva da produção de mediadores lipídicos na resposta imune contra COVID-19: busca de biomarcadores e novos alvos terapêuticos na evolução da doença |
| Beneficiário: | Lúcia Helena Faccioli |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |