| Texto completo | |
| Autor(es): |
de Figueiredo, Rebeca Machado
;
Falconi-Sobrinho, Luiz Luciano
;
Andrade Leite-Panissi, Christie Ramos
;
Huston, Joseph P.
;
Mattern, Claudia
;
de Carvalho, Milene Cristina
;
Coimbra, Norberto Cysne
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF PSYCHOPHARMACOLOGY; v. 36, n. 11, p. 16-pg., 2022-10-14. |
| Resumo | |
Background: Panic-like reactions elicited by electrical stimulation of the dorsal periaqueductal grey matter (ES-dPAG) seem to be regulated by dopamine (DA). We showed that DA applied intranasally (IN) increased escape-behaviour thresholds induced by ES-dPAG of rats, indicating a panicolytic-like effect. Aims: We investigated whether IN-DA increases escape-response thresholds induced by ES-dPAG by acting on D-2-like receptors, and whether IN-DA affects escape responses elicited by the presence of a potential predator and by open space and height of the elevated T-maze (ETM) as well as motor performance in the open field (OF) test. Methods: Wistar rats exposed to ES-dPAG were treated with Sulpiride (SUL, 40 mg/kg, D-2-like receptor antagonist) previously IN-DA (2 mg/kg). Independent groups of rats treated with IN-DA were submitted to prey versus snake paradigm (PSP), ETM and OF. Results: Anti-aversive effects of the IN-DA were reduced by SUL pretreatment in the ES-dPAG test. IN-DA did not affect the escape number in the PSP nor the escape latencies in the ETM as well as motor performance in the OF. Conclusions/interpretation: The IN-DA effects in reducing unconditioned fear responses elicited by ES-dPAG seem to be mediated by D-2-like receptors. The lack of effects on panic-related responses in the ETM and PSP may be related to the possibility of avoiding the danger inherent to these models, a defence strategy not available during ES-dPAG. These findings cannot be attributed to motor performance. The decision-making responses to avoid dangerous situations can be orchestrated by supra-mesencephalic structures connected by non-dopaminergic inputs. (AU) | |
| Processo FAPESP: | 17/11855-8 - Estudo da influência de endocanabinoides do corpo estriado e do mesencéfalo ventral na atividade das projeções GABAérgicas neoestriado-nigro-tectais durante as reações de pânico de roedores ameaçados por serpentes peçonhentas |
| Beneficiário: | Norberto Cysne Coimbra |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 13/10984-8 - Influência do córtex cingulado anterior e o envolvimento de receptores glutamatérgicos NMDA e AMPA/Cainato hipotalâmicos na organização do comportamento de defesa e da antinocicepção induzidos pelo medo, elaborados pelo hipotálamo posterior |
| Beneficiário: | Luiz Luciano Falconi Sobrinho |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 19/05255-3 - Estudo da influência de vias glutamatérgicas do córtex cingulado anterior em mecanismos nitrérgicos do hipotálamo ventromedial e da substância cinzenta periaquedutal envolvidos na geração de respostas defensivas de camundongos ameaçados por serpentes |
| Beneficiário: | Luiz Luciano Falconi Sobrinho |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 20/15050-7 - Estudo do papel da sinalização endocanabinoide e endovaniloide no paleoestriado, na atividade do duplo elo conectivo GABAérgico neoestriado-pálido-nigro-tectal durante a organização do medo instintivo de animais confrontados com serpentes |
| Beneficiário: | Norberto Cysne Coimbra |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |