Cognitive impairment in long-COVID and its association with persistent dysregulation in inflammatory markers

Autor(es):Mostrar menos -

Damiano, Rodolfo Furlan ; Rocca, Cristiana Castanho de Almeida ; Serafim, Antonio de Padua M. ; Loftis, Jennifer ; Talib, Leda Leme ; Pan, Pedro Mario ; Cunha-Neto, Edecio ; Kalil, Jorge ; de Castro, Gabriela Salim ; Seelaender, Marilia F. ; Guedes, Bruno K. ; Marie, Suely K. Nagahashi ; de Souza, Heraldo Possolo ; Nitrini, Ricardo ; Miguel, Euripedes Constantino ; Busatto, Geraldo ; Forlenza, Orestes, V ; HCFMUSP COVID 19 Study Grp

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN IMMUNOLOGY; v. 14, p. 13-pg., 2023-05-23.

Resumo

ObjectiveTo analyze the potential impact of sociodemographic, clinical and biological factors on the long-term cognitive outcome of patients who survived moderate and severe forms of COVID-19. MethodsWe assessed 710 adult participants (Mean age = 55 +/- 14; 48.3% were female) 6 to 11 months after hospital discharge with a complete cognitive battery, as well as a psychiatric, clinical and laboratory evaluation. A large set of inferential statistical methods was used to predict potential variables associated with any long-term cognitive impairment, with a focus on a panel of 28 cytokines and other blood inflammatory and disease severity markers. ResultsConcerning the subjective assessment of cognitive performance, 36.1% reported a slightly poorer overall cognitive performance, and 14.6% reported being severely impacted, compared to their pre-COVID-19 status. Multivariate analysis found sex, age, ethnicity, education, comorbidity, frailty and physical activity associated with general cognition. A bivariate analysis found that G-CSF, IFN-alfa2, IL13, IL15, IL1.RA, EL1.alfa, IL45, IL5, IL6, IL7, TNF-Beta, VEGF, Follow-up C-Reactive Protein, and Follow-up D-Dimer were significantly (p<.05) associated with general cognition. However, a LASSO regression that included all follow-up variables, inflammatory markers and cytokines did not support these findings. ConclusionThough we identified several sociodemographic characteristics that might protect against cognitive impairment following SARS-CoV-2 infection, our data do not support a prominent role for clinical status (both during acute and long-stage of COVID-19) or inflammatory background (also during acute and long-stage of COVID-19) to explain the cognitive deficits that can follow COVID-19 infection. (AU)

• Processo FAPESP: 22/01769-5 - Avaliação tardia dos efeitos físicos, psicológicos e cognitivos em uma coorte de pacientes sobreviventes à internação por COVID-19 em hospital universitário terciário: uma abordagem multidisciplinar
• Beneficiário: Carlos Roberto Ribeiro de Carvalho
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 21/14379-8 - Manifestações psiquiátricas e cognitivas associadas à infecção pelo vírus SARS-CoV-2
• Beneficiário: Rodolfo Furlan Damiano
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 20/02988-7 - Decodificando o impacto do microambiente e das vias de sinalização na saúde e na doença no cérebro, glândula adrenal e rim
• Beneficiário: Suely Kazue Nagahashi Marie
• Modalidade de apoio: Auxílio à Pesquisa - Temático