Exercise training in hypertension: Role of microRNAs

Autor(es)

das Neves, Vander Jose ; Fernandes, Tiago ; Roque, Fernanda Roberta ; Reno Soci, Ursula Paula ; Soares Melo, Stephano Freitas ; de Oliveira, Edilamar Menezes

• Tipo de documento: Artigo Científico
• Fonte: WORLD JOURNAL OF CARDIOLOGY; v. 6, n. 8, p. 15-pg., 2014-08-26.

Resumo

Hypertension is a complex disease that constitutes an important public health problem and demands many studies in order to understand the molecular mechanisms involving his pathophysiology. Therefore, an increasing number of studies have been conducted and new therapies are continually being discovered. In this context, exercise training has emerged as an important non-pharmacological therapy to treat hypertensive patients, minimizing the side effects of pharmacological therapies and frequently contributing to allow pharmacotherapy to be suspended. Several mechanisms have been associated with the pathogenesis of hypertension, such as hyperactivity of the sympathetic nervous system and renin-angiotensin aldosterone system, impaired endothelial nitric oxide production, increased oxygen-reactive species, vascular thickening and stiffening, cardiac hypertrophy, impaired angiogenesis, and sometimes genetic predisposition. With the advent of microRNAs (miRNAs), new insights have been added to the perspectives for the treatment of this disease, and exercise training has been shown to be able to modulate the miRNAs associated with it. Elucidation of the relationship between exercise training and miRNAs in the pathogenesis of hypertension is fundamental in order to understand how exercise modulates the cardiovascular system at genetic level. This can be promising even for the development of new drugs. This article is a review of how exercise training acts on hypertension by means of specific miRNAs in the heart, vascular system, and skeletal muscle. (C) 2014 Baishideng Publishing Group Inc. All rights reserved. (AU)

• Processo FAPESP: 10/50048-1 - Bases celulares e funcionais do exercício físico na doença cardiovascular
• Beneficiário: Carlos Eduardo Negrão
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/10472-7 - O treinamento físico de natação no remodelamento vascular de artérias coronárias de ratos espontaneamente hipertensos: Efeitos na expressão de microRNAs e perspectivas de identificação de alvos terapêuticos.
• Beneficiário: Fernanda Roberta Roque Redondo
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 10/09438-0 - UTILIZAÇÃO TERAPÊUTICA DE microRNAS RESPONSÁVEIS PELA REGULAÇÃO DA CONTRATILIDADE CARDÍACA ASSOCIADO AO TREINAMENTO FÍSICO AERÓBICO EM RATOS COM INSUFICIÊNCIA CARDÍACA
• Beneficiário: Stéphano Freitas Soares Melo
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 12/04104-2 - Expressão de microRNAs na aorta torácica de ratos normotensos submetidos a treinamento físico aeróbio: perspectivas de identificação de alvos terapêuticos relacionados à hipertensão arterial.
• Beneficiário: Vander José das Neves
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado