Diabetes Mellitus and Liver Surgery: The Effect of Diabetes on Oxidative Stress and Inflammation

Autor(es)

Mendes-Braz, Mariana ; Martins, Joilson O.

• Tipo de documento: Artigo Científico
• Fonte: Mediators of Inflammation; v. 2018, p. 11-pg., 2018-01-01.

Resumo

Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycaemia and high morbidity worldwide. The detrimental effects of hyperglycaemia include an increase in the oxidative stress (OS) response and an enhanced inflammatory response. DM compromises the ability of the liver to regenerate and is particularly associated with poor prognosis after ischaemia-reperfusion (I/R) injury. Considering the growing need for knowledge of the impact of DM on the liver following a surgical procedure, this review aims to present recent publications addressing the effects of DM (hyperglycaemia) on OS and the inflammatory process, which play an essential role in I/R injury and impaired hepatic regeneration after liver surgery. (AU)

• Processo FAPESP: 17/11540-7 - Investigando o papel da insulina na vigência da inflamação alérgica pulmonar em camundongos diabéticos e sadios
• Beneficiário: Joilson de Oliveira Martins
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/24992-0 - Estudo do papel do fator de crescimento de fibroblastos 21 (FGF21) como indutor autofágico durante a lesão e regeneração após a ressecção hepática associada à isquemia-reperfusão em camundongos diabéticos e sadios.
• Beneficiário: Mariana Mendes Braz
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado