5-HT2A receptor activation in the dorsolateral septum facilitates inhibitory avoidance in the elevated T-maze

Autor(es)

de Paula, D. C. ^[1] ; Torricelli, A. S. ^[1] ; Lopreato, M. R. ^[1] ; Nascimento, J. O. G. ^[2] ; Viana, M. B. ^[1]

Afiliação do(s) autor(es)

^[1] Fed Univ Sao Paulo UNIFESP, Dept Biosci, Santos, SP - Brazil

^[2] Fed Univ Sao Paulo UNIFESP, Dept Psychiat, Santos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Behavioural Brain Research; v. 226, n. 1, p. 50-55, JAN 1 2012.
• Citações Web of Science: 14

Resumo

Serotonin in the lateral septum has been implicated in the modulation of defense and hence in anxiety. However, it deserves investigation how changes in 5-HT-mechanisms in this area modulate defensive responses associated with specific subtypes of anxiety disorders. We evaluated the effects of intra-dorsolateral septum (DLS) injections of the preferential 5-HT(2A) receptor agonist DOI (8 and 16 nmol), the 5-HT(2C) selective agonist MK-212 (0.1 and 1 nmol) and the preferential 5-HT(2A) antagonist ketanserin (10 and 20 nmol) in rats exposed to the elevated T-maze (ETM), a model which allows the measurement of two defensive responses: inhibitory avoidance and escape. These responses have been respectively related to generalized anxiety and panic disorder. All animals were tested in an open-field after the ETM for locomotor activity assessments. Results showed that intra-DLS DOI increased avoidance latencies, an anxiogenic effect. MK and ketanserin were without effect. Also, none of the drugs administered affected the escape performance. Ketanserin blocked the anxiogenic effect caused by DOL. No changes to locomotion were observed. The data suggests that DLS 5-HT(2A) receptors are involved in the control of inhibitory avoidance and that a failure in this mechanism may be of importance to the physiopathology of generalized anxiety. (C) 2011 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 08/58815-1 - Efeito da administracao cronica de corticosterona sobre medidas de ansiedade e memoria e sobre a neurogenese hipocampal
• Beneficiário: Milena de Barros Viana
• Modalidade de apoio: Auxílio à Pesquisa - Regular