Photochemical Synthesis and Ring-Opening of Aziridines and Epoxides: State-of-the-Art

Autor(es)

Furniel, Lucas G. ; Correa, Arlene G.

• Tipo de documento: Artigo Científico
• Fonte: CHEMPHOTOCHEM; v. 8, n. 9, p. 18-pg., 2024-06-15.

Resumo

The development of greener methods for the preparation of three-membered rings has increased in the last decade, not only due to their biological activity but also to the ring strain of those heterocycles that make them useful precursors of more complex molecules. In this work, the visible-light-promoted synthesis and ring-opening of aziridines and epoxides, reported in the last five years, were reviewed. Both homogeneous and heterogeneous catalysts were discussed and, in addition, the plausible mechanism pathways were highlighted. Aziridines and epoxides exhibit diverse biological activity and wide utility as precursors for more complex structures. Their combination with visible-light photocatalysis offers a versatile and greener synthetic tool. Therefore, the progress in photochemical and photocatalytic synthesis or ring-opening methods of these important strained heterocycles, reported in the last five years, is presented in this review. image (AU)

• Processo FAPESP: 23/11454-4 - Síntese fotocatalítica de 1-pirrolinas sob condições de fluxo contínuo e síntese de pirrolo[2,1-a]isoquinolinas para avaliação de atividade antiplasmodial
• Beneficiário: Lucas Giani Furniel
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 21/12394-0 - Métodos sintéticos sustentáveis empregando catálise, solventes verdes, reagentes seguros e materiais de partida renováveis
• Beneficiário: Arlene Gonçalves Corrêa
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/07600-3 - CIBFar - Centro de Inovação em Biodiversidade e Fármacos
• Beneficiário: Glaucius Oliva
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs