Antiproliferative Activity of Three Methoxylated Flavonoids Isolated from Zeyheria montana Mart. (Bignoniaceae) Leaves

Autor(es)

Seito, Leonardo Noboru ^[1] ; Tasca Goiz Ruiz, Ana Lucia ^[2] ; Vendramini-Costa, Debora ^[2] ; Tinti, Sirlene Valerio ^[2] ; de Carvalho, Joao Ernesto ^[2] ; Bastos, Jairo Kenupp ^[3] ; Di Stasi, Luiz Claudio ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista UNESP, Lab Phytomed, Dept Pharmacol, Inst Biociencias, BR-18618000 Botucatu, SP - Brazil

^[2] Univ Estadual Campinas, Ctr Pluridisciplinar Pesquisas Quim Biol & Agr, UNICAMP, BR-13083970 Campinas, SP - Brazil

^[3] Univ Sao Paulo, Lab Farmacognosia, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Phytotherapy Research; v. 25, n. 10, p. 1447-1450, OCT 2011.
• Citações Web of Science: 15

Resumo

The present study isolated three major active flavonoids, two flavones named 4',5,7-trimethoxy-luteolin (1) and 6-hydroxy-5,7-dimethoxyflavone (2) and the flavanone 5-hydroxy-6,7-dimethoxyflavanone (3) from Zeyheria montana dichloromethane leaf extract. Isolation and purification were conducted with the application of column chromatography and structures were assigned by spectral analysis. All compounds were evaluated for cytotoxic activities against human tumor cell lines UACC-62 (melanoma), MCF-7 (breast), NCI-ADR/RES (breast expressing phenotype multiple drug resistance), 786-0 (renal), NCI-H460 (lung, non-small cells), PC-3 (prostate), OVCAR-3 (ovarian), HT-29 (colon) and K562 (leukemia) in vitro. All compounds were active in different degrees on several tumor cell lines and flavanone 3 showed cytotoxicity against almost all cell lines, particularly against human NCI-ADR/RES and K562 cell lines. In conclusion, three antiproliferative compounds were isolated for the first time from Zeyheria montana and its leaves were characterized as an important source of methoxylated flavones and flavanone as potential antitumor compounds. Copyright (C) 2011 John Wiley \& Sons, Ltd. (AU)

• Processo FAPESP: 03/09324-1 - Efeitos de cumarinas naturais em modelos experimentais de úlcera, diarréia e inflamação intestinal: um estudo de relação estrutura-atividade
• Beneficiário: Luiz Claudio Di Stasi
• Modalidade de apoio: Auxílio à Pesquisa - Regular