| Texto completo | |
| Autor(es): |
Bragagnolo, Felipe Sanchez
;
Wojeicchowski, Jose Pedro
;
Soukup-Carne, Dominik
;
Gonzalez-Miquel, Maria
;
Esteban, Jesus
;
Funari, Cristiano Soleo
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | SUSTAINABLE CHEMISTRY AND PHARMACY; v. 37, p. 13-pg., 2023-11-23. |
| Resumo | |
Soybeans' genistein and its isomer apigenin are widely studied bioactive compounds owing to their therapeutic potential for treating various health disfunctions. A green extraction of both from soy by-products could lead to a valuable and sustainable approach to adding value to these materials in a biorefinery context. Here Hansen Solubility Parameters (HSP) and the Conductor-like Screening MOdel for Real Solvents (COSMO-RS) were applied to screen green molecular sol-vents and Natural Eutectic Solvents for the extraction of genistein and apigenin from soy by-products. The predicted solubilities of genistein and apigenin in 18 shortlisted candidates were experimentally tested by dynamic maceration, the most industrially implemented natural prod-ucts extraction technique. EtOH:H2O (8:2, v/v) and natural eutectic solvent (NAES) betaine:eth-ylene glycol (1:2, mol/mol) showed the highest performance. These were selected for extraction optimizations by Design of Experiments from soy branches, the largest by-product by mass. The optimum condition of each solvent was applied to extract all other parts of soy collected post-mechanical harvesting. The highest value of apigenin, 591.49 +/- 26.7 mu g/g, was achieved from soy pods with EtOH:H2O (8:2, v/v), while the highest of genistein, 54.04 +/- 3.39 mu g/g, was achieved from soybeans using the same solvent. Our findings highlight the necessity of exercising caution when interpreting in silico outcomes in the context of metabolite extractions from com-plex matrices. A trade-off between in silico solvent screening and experimental work should be followed when developing new phytochemical extraction processes. Furthermore, soy by-products emerged as competitive candidates for a long-term source of the bioactive apigenin in a biorefinery context. (AU) | |
| Processo FAPESP: | 17/06216-6 - Desenvolvimento de metodologias analíticas verdes na busca por compostos orgânicos de alto valor agregado em resíduos agrícolas |
| Beneficiário: | Cristiano Soleo de Funari |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 18/21128-9 - Desenvolvimento de metodologias verdes na investigação química de resíduos de soja (Glycine max (L.) Merr.) e de seus produtos derivados |
| Beneficiário: | Felipe Sanchez Bragagnolo |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 14/50926-0 - INCT 2014: biodiversidade e produtos naturais |
| Beneficiário: | Vanderlan da Silva Bolzani |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa BIOTA - Temático |
| Processo FAPESP: | 22/00645-0 - Valorização integral de subprodutos de soja e de trigo gerados no Brasil e no Reino Unido: uma abordagem de agregação de valor em cascata |
| Beneficiário: | Cristiano Soleo de Funari |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 18/01786-1 - EMU concedido no processo 2017/06216-6: cromatógrafo líquido de ultra alta eficiência |
| Beneficiário: | Cristiano Soleo de Funari |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa Equipamentos Multiusuários |