| Texto completo | |
| Autor(es): |
de Oliveira, Wilson Pascoalino Camargo
;
Freitas, Fatima Rodrigues
;
Costa, Mauricio Tavares
;
Silva, Aline de Oliveira
;
de Cleva, Roberto
;
Filho, Roberto Kalil
;
Santo, Marco Aurelio
;
Maranhao, Raul Cavalcante
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | CLINICAL OBESITY; v. 14, n. 5, p. 7-pg., 2024-06-29. |
| Resumo | |
Obesity increases serum triglycerides and decreases high-density lipoprotein cholesterol (HDL-C). The objective is to explore some functions of HDL, cholesterol transfers and antioxidant, in subjects with grade I (G1-OB) and III (G3-OB) obesity and effects of bariatric surgery on G3-OB. Fifteen G3-OB patients (43 +/- 6 years, BMI 49 +/- 3 kg/m(2)) were studied before and 1 year after bariatric surgery; 15 G1-OB (32 +/- 2 years, 32 +/- 2 kg/m(2)) and 15 normal weight (NW) (38 +/- 6 years, 22 +/- 1 kg/m(2)) were also studied. HDL diameter, cholesterol transfer to HDL and antioxidant capacity of HDL were determined. G3-OB had higher triglycerides and lower HDL-C; G1-OB had higher triglycerides than NW but HDL-C was equal. Compared to NW, HDL size was smaller in G3-OB but equal in G1-OB. One year after bariatric surgery, BMI and triglycerides of G3-OB decreased (p < .0001 and p = .0012, respectively) and HDL-C increased (p < .0001), equalling of NW group. Antioxidant capacity and cholesterol transfers were not different in groups and were unchanged 1 year after bariatric surgery in G3-OB. HDL antioxidant capacity and transfer of cholesterol to HDL were not defective in obesity despite HDL-C reduction and smaller HDL size. In addition, pronounced weight loss by bariatric surgery did not change those protective functions. (AU) | |
| Processo FAPESP: | 14/03742-0 - Projeto temático em medicina translacional: nanopartículas que se ligam a receptores de lipoproteínas no tratamento da aterosclerose, do infarto agudo de miocárdio, do pós-transplante de coração, do câncer e da endometriose |
| Beneficiário: | Raul Cavalcante Maranhao |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |