Latin America's Dengue Outbreak Poses a Global Health Threat

Autor(es)

de Almeida, Michelle Teixeira ; Merighi, Davi Gabriel Salustiano ; Visnardi, Aline Biazola ; Goncalves, Caue Augusto Boneto ; Amorim, Vitor Martins de Freitas ; Ferrari, Anielle Salviano de Almeida ; de Souza, Anacleto Silva ; Guzzo, Cristiane Rodrigues

• Tipo de documento: Artigo Científico
• Fonte: Viruses-Basel; v. 17, n. 1, p. 32-pg., 2025-01-01.

Resumo

Dengue fever, caused by the dengue virus (DENV), poses a significant global health challenge, particularly in tropical and subtropical regions. Recent increases in indigenous DENV cases in Europe are concerning, reflecting rising incidence linked to climate change and the spread of Aedes albopictus mosquitoes. These vectors thrive under environmental conditions like temperature and humidity, which are increasingly influenced by climate change. Additionally, global travel accelerates the cross-border spread of mosquito-borne diseases. DENV manifests clinically in a spectrum from asymptomatic cases to severe conditions like dengue hemorrhagic fever and dengue shock syndrome, influenced by viral serotype and host factors. In 2024, Brazil experienced a fourfold increase in dengue cases compared to 2023, accompanied by higher mortality. Conventional control measures, such as vector control, community engagement, and vaccination, proved insufficient as climate change exacerbated mosquito proliferation, challenging containment efforts. In this regard, our review analyzes prevention measures and therapeutic protocols during the outbreak while addressing DENV transmission dynamics, clinical presentations, and epidemiological shifts. It also evaluates diagnostic strategies combining clinical assessment with serological and molecular testing, providing information to improve diagnostic and preventive measures. The global expansion of dengue-endemic regions, including outbreaks in Europe, highlights the urgent need for enhanced surveillance, proactive interventions, and international collaboration to mitigate the growing threat of Dengue and other arboviruses like West Nile, Zika, Chikungunya, Oropouche, and Yellow Fever viruses. (AU)

• Processo FAPESP: 23/13894-1 - Estudo por criomicroscopia eletrônica da adsorção de um fago ao pilus tipo IV
• Beneficiário: Davi Gabriel Salustiano Merighi
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 21/05262-0 - Estudo da sinalização c-di-GMP envolvendo LIC_11920 em Leptospira interrogans
• Beneficiário: Aline Biazola Visnardi
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 21/10577-0 - Centro de Pesquisa em Biologia de Bactérias e Bacteriófagos (CEPID B3)
• Beneficiário: Shaker Chuck Farah
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 23/18211-0 - Triagem virtual em larga escala na busca de inibidores da principal protease do novo coronavírus
• Beneficiário: Anacleto Silva de Souza
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 22/08730-7 - Biologia estrutural de proteínas aplicada na compreensão da sinalização c-di-GMP e de sistemas secretórios bacterianos
• Beneficiário: Cristiane Rodrigues Guzzo Carvalho
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 23/07366-2 - Expressão heteróloga de um homólogo de PilZ para estudo da sinalização c-di-GMP em Leptospira interrogans
• Beneficiário: Cauê Augusto Boneto Gonçalves
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica