New Colletotricandins and Thielavins Isolated from Colletotrichum gloeosporioides

Autor(es)

Mustapha N. Abubakar ^[1] ; Vitor S. Mazucato ^[2] ; Paulo C. Vieira ^[3]

Afiliação do(s) autor(es)

^[1] Universidade de São Paulo. Departamento de Ciências BioMoleculares. Faculdade de Ciências Farmacêuticas de Ribeirão Preto - Brasil

^[2] Universidade de São Paulo. Departamento de Ciências BioMoleculares. Faculdade de Ciências Farmacêuticas de Ribeirão Preto - Brasil

^[3] Universidade de São Paulo. Departamento de Ciências BioMoleculares. Faculdade de Ciências Farmacêuticas de Ribeirão Preto - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Journal of the Brazilian Chemical Society; v. 36, n. 6 2025-03-31.

Resumo

This study investigates the chemical diversity and compares the metabolites of Colletotrichum gloeosporioides extracted from potato dextrose broth (PDB) and rice media. C. gloeosporioides is a fungal pathogen known for compromising protease-rich edible fruits, such as papaya. Comparative analyses of the ethyl acetate extracts using 1H nuclear magnetic resonance (NMR) spectroscopy and gas chromatography-mass spectrometry (CG-MS) reveal significant variations in chemical diversity and enhanced metabolite production in rice media compared to PDB. High-performance liquid chromatographic technique applied to the rice ethyl acetate extract led to the identification of two new derivatives of colletotricandin, designated C and D, as well as two additional derivatives of thielavin, named 3-demethylthielavin M and 3”,3’-didemethyl-3-methylthielavin N. These newly identified compounds were thoroughly analyzed alongside previously known metabolites. The structure elucidation of the compounds was performed using NMR, high-resolution mass spectrometry (HR-MS), and GC-MS spectroscopy. (AU)

• Processo FAPESP: 13/07600-3 - CIBFar - Centro de Inovação em Biodiversidade e Fármacos
• Beneficiário: Glaucius Oliva
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 22/10835-1 - Frutos brasileiros comestíveis ricos em proteases e suas explorações microbianas para identificação de novos constituintes bioativos
• Beneficiário: Mustapha Ngaski Abubakar
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado