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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

New Colletotricandins and Thielavins Isolated from Colletotrichum gloeosporioides

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Author(s):
Mustapha N. Abubakar [1] ; Vitor S. Mazucato [2] ; Paulo C. Vieira [3]
Total Authors: 3
Affiliation:
[1] Universidade de São Paulo. Departamento de Ciências BioMoleculares. Faculdade de Ciências Farmacêuticas de Ribeirão Preto - Brasil
[2] Universidade de São Paulo. Departamento de Ciências BioMoleculares. Faculdade de Ciências Farmacêuticas de Ribeirão Preto - Brasil
[3] Universidade de São Paulo. Departamento de Ciências BioMoleculares. Faculdade de Ciências Farmacêuticas de Ribeirão Preto - Brasil
Total Affiliations: 3
Document type: Journal article
Source: Journal of the Brazilian Chemical Society; v. 36, n. 6 2025-03-31.
Abstract

This study investigates the chemical diversity and compares the metabolites of Colletotrichum gloeosporioides extracted from potato dextrose broth (PDB) and rice media. C. gloeosporioides is a fungal pathogen known for compromising protease-rich edible fruits, such as papaya. Comparative analyses of the ethyl acetate extracts using 1H nuclear magnetic resonance (NMR) spectroscopy and gas chromatography-mass spectrometry (CG-MS) reveal significant variations in chemical diversity and enhanced metabolite production in rice media compared to PDB. High-performance liquid chromatographic technique applied to the rice ethyl acetate extract led to the identification of two new derivatives of colletotricandin, designated C and D, as well as two additional derivatives of thielavin, named 3-demethylthielavin M and 3”,3’-didemethyl-3-methylthielavin N. These newly identified compounds were thoroughly analyzed alongside previously known metabolites. The structure elucidation of the compounds was performed using NMR, high-resolution mass spectrometry (HR-MS), and GC-MS spectroscopy. (AU)

FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
Grantee:Glaucius Oliva
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 22/10835-1 - Brazilian protease-rich edible fruits and their microbial explorations for the identification of novel bioactive constituents
Grantee:Mustapha Ngaski Abubakar
Support Opportunities: Scholarships in Brazil - Post-Doctoral