Rational exploration of Colletotrichum gloeosporiodes, aiming at the production and isolation of bioactive metabolites and scale-up processes

• Grant number: 19/07603-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2019
• End date: January 19, 2020
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Ian Castro-Gamboa
• Grantee: Pietro Cotta Galvão
• Host Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Associated research grant: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery, AP.CEPID

Abstract

Natural products have always been an important source of drugs and compounds with bioactive properties, but the discovery of new compounds has been declining in recent years, due to the knowledge of the main chemotypes found in plants. In an attempt to overcome this problem, the chemistry of natural products has sought other alternatives, including the use of sources still underutilized, such as endophytic microorganisms and those found in the rhizosphere, including the use of agile methodologies in the detection of compounds already reported in the literature, contemplated in the approach of the dereplication and employing the statistical tools of chemometrics. In addition, culture techniques which stimulate the chemical variety are also applied, systematically varying the culture medium used, in order to induce the production of different secondary metabolites. This project aims to study the fungus Colletotrichum gloeosporioides, an endophyte microorganism of the fruit tree Garcinia xanthochymus, aiming at a more detailed study of the secondary metabolites produced, which are little detailed in the literature, and its application in bioreactors.