| Texto completo | |
| Autor(es): |
de Menezes, Caroline
;
Campolim, Clara Machado
;
Triana, Angie
;
de Oliveira, Kenia Moreno
;
Calixto, Leticia Gama S.
;
Xavier, Fernanda Garofalo
;
Saad, Mario J. A.
;
Carneiro, Everardo Magalhaes
;
Prada, Patricia O.
Número total de Autores: 9
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NUTRIENTS; v. 17, n. 19, p. 22-pg., 2025-09-30. |
| Resumo | |
Background/Objectives: The consumption of highly palatable ultra-processed foods (UPFs), enriched in sugar, saturated fat, and salt, increases the risk of morbidity and mortality by inducing obesity, type 2 diabetes (T2DM), cardiovascular disease, and cancer. The present study aimed to investigate the impact of a UPF-rich diet on adiposity, feeding behavior, glucose homeostasis, intestinal barrier markers, expression of inflammatory cytokines, and microbiota in male and female C57BL/6J mice. Methods: Animals received a chow diet or a UPF diet for 10 (UPF10) or 30 days (UPF30). UPF10 induced greater calorie intake as early as 10 days on a UPF diet. Fat accumulation occurs in both sexes, specifically after 30 days of exposure. Results: The duration of UPF exposure significantly influenced glucose metabolism and insulin sensitivity. A 10-day UPF diet was associated with lower fasting blood glucose levels, without higher insulin levels, in both sexes. Females showed early impairment in glucose tolerance. Male mice on UPF30 exhibited elevated systemic IL-6 levels, as well as reduced intestinal expression of Occludin and E-cadherin genes. In females, UPF30 increased TNF-alpha expression in the gut and increased microbial diversity. Both sexes displayed dysbiosis, with females showing pronounced changes in the proportion between predominant phyla, and males showing more specific changes in bacterial genera. Conclusions: A diet high in UPFs promoted metabolic, inflammatory, and gut microbiota alterations, with effects varying according to exposure duration and biological context, and becoming more pronounced after 30 days. (AU) | |
| Processo FAPESP: | 17/11518-1 - Estudo sobre os efeitosda poluição atmosféricanagêneseda obesidade: o papel da ativação do toll like receptor 4 hipotalâmico |
| Beneficiário: | Clara Machado Campolim |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 17/18498-6 - Impacto da exposição perinatal a poluentes ambientais na gênese da obesidade e diabetes mellitus tipo 2: aspectos metabólicos e epigenéticos |
| Beneficiário: | Patrícia de Oliveira Prada |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 24/10960-6 - Análise molecular e funcional da síntese, secreção e ação do peptídeo semelhante ao glucagon 1 (GLP-1) sobre a função da célula ²-pancreática na dupla carga de má nutrição |
| Beneficiário: | Kênia Moreno de Oliveira |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 18/26080-4 - Caracterização dos mecanismos moleculares e funcionais envolvidos nas disfunções endócrino-metabólicas, cardiovasculares e neurais induzidas pela restrição de aminoácidos in vitro e in vivo: possível papel terapêutico do ácido biliar TUDCA |
| Beneficiário: | Everardo Magalhães Carneiro |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |