Plasma iron levels appraised 15 days after spinal cord injury in a limb movement animal model

Autor(es)

Reis, F. M. ^{[1, 2]} ; Esteves, A. M. ^{[1, 2]} ; Tufik, S. ^{[1, 3, 2]} ; de Mello, M. T. ^{[1, 3, 2]}

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Ctr Estudos Psicobiol & Exercicio, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Dept Psicobiol, BR-04020060 Sao Paulo - Brazil

^[3] Associacao Fundo Incent Psicofarmacol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SPINAL CORD; v. 49, n. 3, p. 361-364, MAR 2011.
• Citações Web of Science: 1

Resumo

Study design: Experimental, controlled trial. Objectives: The purpose of this study was to evaluate plasma iron and transferrin levels in a limb movement animal model with spinal cord injury (SCI). Setting: Universidade Federal de Sao Paulo, Departamento de Psicobiologia. Methods: In all, 72 male Wistar rats aged 90 days were divided into four groups: (1) acute SCI (1 day, SCI1), (2) 3 days post-SCI (SCI3), (3) 7 days post-SCI (SCI7) and (4) 15 days post-SCI (SCI15). Each of these groups had corresponding control (CTRL) and SHAM groups. Plasma iron and transferrin levels of the different groups were analyzed using a one-way analysis of variance (ANOVA) followed by Tukey's test. Results: We found a significant reduction in iron plasma levels after SCI compared with the CTRL group: SCI1 (CTRL: 175 +/- 10.58 mu gdl +/-; SCI: 108.28 +/- 11.7 mu gdl(-1)), SCI3 (CTRL: 195.5 +/- 11.00 mu gdl(-1); SCI: 127.88 +/- 12.63 mu gdl(-1)), SCI7 (CTRL: 186 +/- 2.97 mu gdl(-1); SCI: 89.2 +/- 15.39 mu gdl(-1)) and SCI15 (CTRL: 163 +/- 5.48 mu gdl(-1); SCI: 124.44 +/- 10.30 mu gdl(-1)) (P < 0.05; ANOVA). The SHAM1 group demonstrated a reduction in iron plasma after acute SCI (CTRL: 175 +/- 10.58 mu gdl(-1); SHAM: 114.60 +/- 7.81 mu gdl(-1)) (P < 0.05; ANOVA). Conclusion: Reduced iron metabolism after SCI may be one of the mechanisms involved in the pathogenesis of sleep-related movement disorders. Spinal Cord (2011) 49, 361-364; doi:10.1038/sc.2010.121; published online 7 September 2010 (AU)

• Processo FAPESP: 03/06297-3 - Avaliacao dos efeitos do exercicio fisico aerobio nos movimentos periodicos de pernas.
• Beneficiário: Andrea Maculano Esteves
• Modalidade de apoio: Bolsas no Brasil - Doutorado