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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Plasma iron levels appraised 15 days after spinal cord injury in a limb movement animal model

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Author(s):
Reis, F. M. [1, 2] ; Esteves, A. M. [1, 2] ; Tufik, S. [1, 3, 2] ; de Mello, M. T. [1, 3, 2]
Total Authors: 4
Affiliation:
[1] Univ Fed Sao Paulo, Ctr Estudos Psicobiol & Exercicio, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Psicobiol, BR-04020060 Sao Paulo - Brazil
[3] Associacao Fundo Incent Psicofarmacol, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: SPINAL CORD; v. 49, n. 3, p. 361-364, MAR 2011.
Web of Science Citations: 1
Abstract

Study design: Experimental, controlled trial. Objectives: The purpose of this study was to evaluate plasma iron and transferrin levels in a limb movement animal model with spinal cord injury (SCI). Setting: Universidade Federal de Sao Paulo, Departamento de Psicobiologia. Methods: In all, 72 male Wistar rats aged 90 days were divided into four groups: (1) acute SCI (1 day, SCI1), (2) 3 days post-SCI (SCI3), (3) 7 days post-SCI (SCI7) and (4) 15 days post-SCI (SCI15). Each of these groups had corresponding control (CTRL) and SHAM groups. Plasma iron and transferrin levels of the different groups were analyzed using a one-way analysis of variance (ANOVA) followed by Tukey's test. Results: We found a significant reduction in iron plasma levels after SCI compared with the CTRL group: SCI1 (CTRL: 175 +/- 10.58 mu gdl +/-; SCI: 108.28 +/- 11.7 mu gdl(-1)), SCI3 (CTRL: 195.5 +/- 11.00 mu gdl(-1); SCI: 127.88 +/- 12.63 mu gdl(-1)), SCI7 (CTRL: 186 +/- 2.97 mu gdl(-1); SCI: 89.2 +/- 15.39 mu gdl(-1)) and SCI15 (CTRL: 163 +/- 5.48 mu gdl(-1); SCI: 124.44 +/- 10.30 mu gdl(-1)) (P < 0.05; ANOVA). The SHAM1 group demonstrated a reduction in iron plasma after acute SCI (CTRL: 175 +/- 10.58 mu gdl(-1); SHAM: 114.60 +/- 7.81 mu gdl(-1)) (P < 0.05; ANOVA). Conclusion: Reduced iron metabolism after SCI may be one of the mechanisms involved in the pathogenesis of sleep-related movement disorders. Spinal Cord (2011) 49, 361-364; doi:10.1038/sc.2010.121; published online 7 September 2010 (AU)