Effects of low intensity laser therapy in Neuroplasticity and Functional Recovery of Spinal Cord Injury

• Grant number: 13/03469-0
• Support Opportunities: Scholarships in Brazil - Master
• Start date: July 01, 2013
• End date: May 31, 2015
• Field of knowledge: Health Sciences - Physiotherapy and Occupational Therapy
• Principal Investigator: Flávia de Oliveira
• Grantee: Suellen de Oliveira Veronez Silva
• Host Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil

Abstract

Recently many means have been studied in an attempt to reach the spinal cord recovery after spinal cord injury. Low-intensity laser therapy (LLLT) has been proposed as a potential treatment agent after lesions of the Central and Peripheral Nervous System. Given the above, the aims this study is evaluate the best parameter and the effects of LLLT in neuroplastic processes and functional after spinal cord injury in an experimental model. Will be used 42 rats, which will be divided into 6 groups: G1 and G2 will be part of the control group and shall be subject only to spinal cord injury and the time of sacrifice will be 7 and 15 days respectively. The G3 and G4 - experimental group that will undergo spinal cord injury and receive laser treatment for 7 consecutive days after injury, and the G3 will receive 10J/cm2 fluency and fluency G4 receive 50J/cm2. And the G5 and G6 - experimental group will undergo spinal cord injury and receive laser treatment for 15 consecutive days after injury, and the G5 receive 10J/cm2 fluency and fluency G6 receive 50J/cm2, application laser is directly above the site of injury. The laser equipment used will be of aluminum and gallium arsenide (GaAlAs) (DMC Teralaser São Carlos, SP, Brazil), with ferrule 0.028cm2, wavelength 808nm, power of 100 mW at fluences of 10J/cm2 and 50J / cm2. The animals will be sacrificed 24 hours after the last treatment day and will be performed histological, immunohistochemical, morphometric and biomechanical. After, there will be statistical analysis applicable to each variable.

Scientific publications

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

SUELLEN DE OLIVEIRA VERONEZ SILVA; LÍVIA ASSIS; PAULA FERNANDA GALLANI MARTIN DEL CAMPO; KATHERINE CHUERE NUNES DUARTE; FLAVIA DE OLIVEIRA; GLAUCIA MONTEIRO DE CASTRO; ANA CLAUDIA MUNIZ RENNO; CARLA CHRISTINA MEDALHA. Low-Level Laser Therapy and Spinal Cord Injury: Effects of 3 Different Fluences in the Intermediate Period of Repair in an Experimental Model in Rats. Brazilian Archives of Biology and Technology, v. 63, 2020-07-24. (13/03469-0)