The anticancer drug tamoxifen is active against Trypanosoma cruzi in vitro but ineffective in the treatment of the acute phase of Chagas disease in mice

Autor(es)

Miguel, Danilo Ciccone ^[1] ; Ferraz, Marcela Lencine ^[2] ; Alves, Rosana de Oliveira ^[2] ; Yokoyama-Yasunaka, Jenicer K. U. ^[1] ; Torrecilhas, Ana Claudia ^[1] ; Romanha, Alvaro Jose ^[2] ; Uliana, Silvia R. B. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Parasitol, Inst Ciencias Biomed, BR-05508000 Sao Paulo - Brazil

^[2] Inst Pesquisas Rene Rachou Fiocruz, Lab Parasitol Celular & Mol, Belo Horizonte, MG - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Memórias do Instituto Oswaldo Cruz; v. 105, n. 7, p. 945-948, NOV 2010.
• Citações Web of Science: 6

Resumo

The activity of the antineoplastic drug tamoxifen was evaluated against Trypanosoma cruzi. In vitro activity was determined against epimastigote, trypomastigote and amastigote forms of CL14, Y and Y benznidazole resistant T. cruzi strains. Regardless of the strain used, the drug was active against all life-cycle stages of the parasite with a half maximal effective concentration ranging from 0.7-17.9 µM. Two experimental models of acute Chagas disease were used to evaluate the in vivo efficacy of treatment with tamoxifen. No differences in parasitemia and mortality were observed between control mock-treated and tamoxifen-treated mice. (AU)

• Processo FAPESP: 05/59881-0 - Investigação de mecanismos de ação do tamoxifeno em parasitas do gênero Leishmania e estudo de sua eficácia no tratamento da leishmaniose experimental
• Beneficiário: Danilo Ciccone Miguel
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto